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J. Clin. Med. 2019, 8(2), 230; https://doi.org/10.3390/jcm8020230

The Relationship between Platelet Count and Host Gut Microbiota: A Population-Based Retrospective Cross-Sectional Study

1
Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul 07804, Korea
2
Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul 03181, Korea
3
Division of Pulmonology, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea
4
Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul 04514, Korea
5
Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul 03181, Korea
6
Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea
7
Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Received: 13 December 2018 / Revised: 7 February 2019 / Accepted: 7 February 2019 / Published: 10 February 2019
(This article belongs to the Section Microbiology & Parasitology)
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Abstract

Platelet count reflects the severity and prognosis of multiple diseases. Additionally, alterations in gut microbiota have been linked to several chronic diseases. The purpose of this study was to investigate the association between gut microbiota and platelet count. We selected 1268 subjects with fecal 16S RNA gene sequencing data from a Healthcare Screening Center cohort. Based on the third quartile of platelets (277 × 109/L), we compared the gut microbiota between the upper quartile (n = 321) and lower three quartiles groups (n = 947). The upper quartile group had lower alpha diversity based on observed amplicon sequence variants (q = 0.004) and phylogenetic index (q < 0.001) than the lower three quartiles group. Significant differences were also found in the weighted UniFrac distance (q = 0.001) and Jaccard dissimilarity (q = 0.047) beta diversity measures between the two groups. Compared with the lower three quartiles group, the upper quartile group exhibited decreased relative abundances of the genus Faecalibacterium, which was also inversely correlated with the platelet count. Increased platelet count was associated with reduced diversity in gut microbiota and lower abundances of Faecalibacterium with beneficial gut bacteria spices F. prausnitzii, suggesting that an increased platelet count, even within normal range, may adversely affect gut microbial diversity and composition. View Full-Text
Keywords: gut microbiota; 16S RNA; platelet; thrombocytosis; Faecalibacterium gut microbiota; 16S RNA; platelet; thrombocytosis; Faecalibacterium
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    Description: Table S1. Comparison of commodities between the upper and lower 3 quartile groups; Table S2. Comparison of nutritional status between the upper and lower 3 quartile groups; Table S3. Comparisons of baseline demographics and laboratory findings between the upper and lower 3 quartile groups within males and females; Table S4. The comparison of microbiome composition between the upper and lower 3 quartile groups in females; Figure S1. Comparison of alpha diversity indexes between the upper and lower 3 quartile groups in the males; Figure S2. Comparison of alpha diversity indexes between the upper and lower 3 quartile groups in the females; Figure S3. The beta diversity distances from lower 3 quartile groups measuring different methods in males; Figure S4. The beta diversity distances from lower 3 quartile groups measuring different methods in females; Figure S5. Prediction of metagenome functional content correlated with platelet count using PICRUSt
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Yoon, H.-Y.; Kim, H.-N.; Lee, S.H.; Kim, S.J.; Chang, Y.; Ryu, S.; Shin, H.; Kim, H.-L.; Lee, J.H. The Relationship between Platelet Count and Host Gut Microbiota: A Population-Based Retrospective Cross-Sectional Study. J. Clin. Med. 2019, 8, 230.

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