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J. Clin. Med. 2019, 8(2), 156; https://doi.org/10.3390/jcm8020156

Neoadjuvant Chemotherapy with Taxane and Platinum Followed by Radical Hysterectomy for Stage IB2-IIB Cervical Cancer: Impact of Histology Type on Survival

1
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90089, USA
2
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
3
Department of Obstetrics and Gynecology, Tottori University, Tottori 683-8504, Japan
4
Department of Obstetrics and Gynecology, Tohoku University, Miyagi 980-8577, Japan
5
Department of Gynecologic Oncology, Hyogo Cancer Center, Hyogo 673-0021, Japan
6
Matsue City Hospital, Shimane 690-8509, Japan
7
Department of Obstetrics and Gynecology, Mie University Hospital, Mie 514-8507, Japan
8
Department of Obstetrics and Gynecology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima 730-8518, Japan
9
Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan
10
Department of Obstetrics and Gynecology, Faculty of Medicine, Nihon University School of Medicine, Tokyo 173-8610, Japan
11
Department of Obstetrics and Gynecology, Tokai University, Kanagawa 259-1193, Japan
12
Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-0023, Japan
*
Authors to whom correspondence should be addressed.
Authors contributed equally to the work.
Received: 25 December 2018 / Revised: 24 January 2019 / Accepted: 27 January 2019 / Published: 30 January 2019
(This article belongs to the Section Obstetrics & Gynecology)
Full-Text   |   PDF [626 KB, uploaded 20 February 2019]   |  

Abstract

The current study examined the histology-specific impact of neoadjuvant chemotherapy (NACT) with a taxane/platinum regimen on survival in women with locally-advanced cervical cancer who underwent radical hysterectomy. This nation-wide retrospective cohort study examined women with clinical stage IB2-IIB cervical cancer who received NACT prior to radical hysterectomy from 2004–2008 (n = 684). NACT type (taxane/platinum versus others) was correlated with survival based on histology: 511 squamous versus 173 non-squamous. Taxane/platinum chemotherapy use was more common in non-squamous compared to squamous tumors (53.8% versus 20.7%, P < 0.001). In both histology types, the taxane/platinum regimen was more frequently utilized over time (both, P < 0.01). Among squamous tumors, women who received taxane/platinum chemotherapy had survival comparable to those who received other regimens: 5-year rates for disease-free survival, 69.0% versus 70.1%, P = 0.98; and cause-specific survival, 80.0% versus 81.0%, P = 0.93. Similarly, in non-squamous tumors, disease-free survival (5-year rates: 60.4% versus 59.0%, P = 0.86) and cause-specific survival (74.7% versus 76.3%, P = 0.70) were similar. In conclusion, use of taxane/platinum regimens for NACT significantly increased during the study period. Irrespective of histology type, in women with clinical stage IB2-IIB cervical cancer who underwent NACT prior to radical hysterectomy, taxane/platinum regimens had a similar effect on survival compared to non-taxane/platinum regimens. View Full-Text
Keywords: cervical cancer; neoadjuvant chemotherapy; radical hysterectomy; locally advanced; squamous; adenocarcinoma cervical cancer; neoadjuvant chemotherapy; radical hysterectomy; locally advanced; squamous; adenocarcinoma
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Matsuo, K.; Shimada, M.; Yamaguchi, S.; Kigawa, J.; Tokunaga, H.; Tabata, T.; Kodama, J.; Kawana, K.; Mikami, M.; Sugiyama, T. Neoadjuvant Chemotherapy with Taxane and Platinum Followed by Radical Hysterectomy for Stage IB2-IIB Cervical Cancer: Impact of Histology Type on Survival. J. Clin. Med. 2019, 8, 156.

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