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J. Clin. Med. 2019, 8(2), 147; https://doi.org/10.3390/jcm8020147

Does Resveratrol Play a Role in Decreasing the Inflammation Associated with Contrast Induced Nephropathy in Rat Model?

1,2,3
,
1,4,5
and
1,4,6,7,*
1
Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan
2
Department of Nephrology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427, Taiwan
3
School of Medicine, Tzu Chi University, Hualien 907, Taiwan
4
School of Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan
5
Section of Pediatric Cardiology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung 407, Taiwan
6
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
7
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
*
Author to whom correspondence should be addressed.
Received: 24 December 2018 / Revised: 13 January 2019 / Accepted: 24 January 2019 / Published: 27 January 2019
(This article belongs to the Section Nephrology & Urology)
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Abstract

Contrast is widely used in invasive image examinations such as computed tomography (CT) and angiography; however, the risk of contrast-induced nephropathy (CIN) is high. The aim of this study was to investigate the protective effect of resveratrol in a rat model of CIN. Sprague-Dawley rats were divided into four groups: the control group (0.9% saline infusion only); resveratrol group (RSV, resveratrol, 30 mg/kg); contrast media group (CIN); and resveratrol + contrast media group (RCIN, resveratrol 30 mg/kg 60 min before CIN). CIN was induced via an intravenous injection of a single dose of indomethacin (10 mg/kg), one dose of N-nitro-L-arginine methyl ester (10 mg/kg), and a single dose of contrast medium iopromide (2 g/kg). Blood urea nitrogen, creatinine, and neutrophil gelatinase-associated lipocalin (NGAL) were higher in the CIN group compared to the other groups. Histopathological tubule injury scores were also higher in the CIN group compared to the other groups (p < 0.01). NLPR3 in kidney tissue were higher in the CIN group compared to the other groups; however, these results were improved by resveratrol in the RCIN group compared with the CIN group. The expressions of IL-1β and the percentage of apoptotic cells were higher in the CIN group than in the control and RSV groups, but they were lower in the RCIN group than in the CIN group. The expression of cleaved caspase-3 was higher in the CIN group than in the control and RSV groups, but lower in the RCIN group than in the CIN group. Resveratrol treatment attenuated both injury processes and apoptosis and inhibited the inflammasome pathway in this rat CIN model. View Full-Text
Keywords: contrast induced nephropathy; resveratrol; inflammasome contrast induced nephropathy; resveratrol; inflammasome
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Chen, Y.-H.; Fu, Y.-C.; Wu, M.-J. Does Resveratrol Play a Role in Decreasing the Inflammation Associated with Contrast Induced Nephropathy in Rat Model? J. Clin. Med. 2019, 8, 147.

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