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One-Stop Management of 230 Consecutive Acute Stroke Patients: Report of Procedural Times and Clinical Outcome
Article

Exercise Training Enhances Platelet Mitochondrial Bioenergetics in Stroke Patients: A Randomized Controlled Trial

1
Department of Physical Medicine and Rehabilitation, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan
2
School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
3
Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
4
Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(12), 2186; https://doi.org/10.3390/jcm8122186
Received: 14 November 2019 / Revised: 5 December 2019 / Accepted: 6 December 2019 / Published: 11 December 2019
(This article belongs to the Section Clinical Cytology)
Exercise training (ET) may impact physical fitness by affecting mitochondrial functions. This study aimed to elucidate the effect of ET on aerobic capacity and platelet mitochondrial bioenergetics (MTB) in stroke patients. Among the 30 stroke patients who underwent the traditional rehabilitation program (TRP), 15 were randomly assigned to have ET (50–60% VO2peak for 30 min/day, 5 days/week for 4 weeks), and those remaining received only the TRP (control group). The peak exercise capacity (VO2peak) and platelet MTB, including oxidative phosphorylation (OXPHOS) and the electron transport chain (ETC), were measured through automatic gas analysis and high-resolution respirometry, respectively. The results demonstrated that ET significantly increased the VO2peak (17.7%) and O2 uptake efficiency slope (31.9%) but decreased the ventilation versus CO2 production slope (−7.65%). Patients who underwent ET also had significantly enhanced platelet mitochondrial OXPHOS and ETC by activating the FADH2 (Complex II)-dependent pathway, but depressed plasma myeloperoxidase (−28.4%) and interleukin-6 levels (−29.9%). Moreover, changes in VO2peak levels were positively correlated with changes in platelet OXPHOS and ETC capacities. In conclusion, ET increases the platelet MTB by enhancing Complex II activity in stroke patients. The exercise regimen also enhances aerobic fitness and depresses oxidative stress/pro-inflammatory status in stroke patients. View Full-Text
Keywords: stroke; exercise training; platelet; mitochondria stroke; exercise training; platelet; mitochondria
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MDPI and ACS Style

Hsu, C.-C.; Tsai, H.-H.; Fu, T.-C.; Wang, J.-S. Exercise Training Enhances Platelet Mitochondrial Bioenergetics in Stroke Patients: A Randomized Controlled Trial. J. Clin. Med. 2019, 8, 2186. https://doi.org/10.3390/jcm8122186

AMA Style

Hsu C-C, Tsai H-H, Fu T-C, Wang J-S. Exercise Training Enhances Platelet Mitochondrial Bioenergetics in Stroke Patients: A Randomized Controlled Trial. Journal of Clinical Medicine. 2019; 8(12):2186. https://doi.org/10.3390/jcm8122186

Chicago/Turabian Style

Hsu, Chih-Chin, Hsing-Hua Tsai, Tieh-Cheng Fu, and Jong-Shyan Wang. 2019. "Exercise Training Enhances Platelet Mitochondrial Bioenergetics in Stroke Patients: A Randomized Controlled Trial" Journal of Clinical Medicine 8, no. 12: 2186. https://doi.org/10.3390/jcm8122186

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