Next Article in Journal
The Association between SOCS1−1656G>A Polymorphism, Insulin Resistance and Obesity in Nonalcoholic Fatty Liver Disease (NAFLD) Patients
Previous Article in Journal
Systematic Balance Exercises Influence Cortical Activation and Serum BDNF Levels in Older Adults
Open AccessArticle

Efficacy and Feasibility of Salvage Re-Irradiation with CyberKnife for In-Field Neck Lymph Node Recurrence: A Retrospective Study

1
CyberKnife Center, Kanto Neurosurgical Hospital, Kumagaya 360-0804, Japan
2
Department of Radiation Oncology, Gunma Prefectural Cancer Center, Ota 373-0828, Japan
3
Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan
4
Department of Radiation Oncology, Toyama University Graduate School of Medicine, Toyama 930-0194, Japan
5
Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku-ku 160-8582, Japan
6
Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka 350-1298, Japan
7
National Institute of Radiological Sciences Hospital, National Institutes for Quantum and Radiological Science and Technology, Inage-ku, Chiba 263-8555, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(11), 1911; https://doi.org/10.3390/jcm8111911
Received: 1 October 2019 / Revised: 5 November 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
(This article belongs to the Section Nuclear Medicine & Radiology)
Neck lymph node (LN) recurrence in the irradiated field represents an important aspect of treatment failure after primary radiotherapy owing to the lack of a standard treatment. The aim of this study is to investigate the efficacy and safety of CyberKnife treatment for neck LN recurrence after radiotherapy. Between 2008 and 2016, 55 neck LN recurrences after radiotherapy in 16 patients were treated with CyberKnife. The median follow-up period was 17 months (range, 2–53 months). The median previous radiotherapy dose was 68 Gy (range, 50–70 Gy). The median marginal dose as equivalent dose delivered in 2-Gy fractions (α/β = 10) was 50 Gy (range, 40–58 Gy). The one-year local control (LC) and overall survival rates were 81% and 71%, respectively. The one-year LC was higher with a target volume ≤1.0 cm3 than that with a target volume >1.0 cm3 (p = 0.006). Fatal bleeding was observed in one patient who had large (91 cm3) and widespread tumor with invasion to the carotid artery before CyberKnife treatment. CyberKnife treatment for neck LN recurrence is safe and feasible in most cases. Indication for the treatment should be carefully considered for large and widespread tumors.
Keywords: salvage treatment; in-field recurrence; re-irradiation; stereotactic radiation therapy; neck lymph node recurrence salvage treatment; in-field recurrence; re-irradiation; stereotactic radiation therapy; neck lymph node recurrence
MDPI and ACS Style

Kobayashi, D.; Sato, H.; Saitoh, J.-I.; Oike, T.; Nakajima, A.; Noda, S.-E.; Kato, S.; Iwanaga, M.; Shimizu, T.; Nakano, T. Efficacy and Feasibility of Salvage Re-Irradiation with CyberKnife for In-Field Neck Lymph Node Recurrence: A Retrospective Study. J. Clin. Med. 2019, 8, 1911.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop