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Open AccessArticle

CMR Tissue Characterization in Patients with HFmrEF

Department of Internal Medicine/Cardiology, German Heart Center Berlin, 13353 Berlin, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Berlin, 10115 Berlin, Germany
Department of Internal Medicine/Cardiology, Charité Campus Virchow Klinikum, 13353 Berlin, Germany
Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania
Philips Healthcare, 22335 Hamburg, Germany
Authors to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(11), 1877;
Received: 11 September 2019 / Revised: 19 October 2019 / Accepted: 30 October 2019 / Published: 5 November 2019
(This article belongs to the Special Issue Acute and Chronic Heart Failure)
The characteristics and optimal management of heart failure with a moderately reduced ejection fraction (HFmrEF, LV-EF 40–50%) are still unclear. Advanced cardiac MRI offers information about function, fibrosis and inflammation of the myocardium, and might help to characterize HFmrEF in terms of adverse cardiac remodeling. We, therefore, examined 17 patients with HFpEF, 18 with HFmrEF, 17 with HFrEF and 17 healthy, age-matched controls with cardiac MRI (Phillips 1.5 T). T1 and T2 relaxation time mapping was performed and the extracellular volume (ECV) was calculated. Global circumferential (GCS) and longitudinal strain (GLS) were derived from cine images. GLS (−15.7 ± 2.1) and GCS (−19.9 ± 4.1) were moderately reduced in HFmrEF, resembling systolic dysfunction. Native T1 relaxation times were elevated in HFmrEF (1027 ± 40 ms) and HFrEF (1033 ± 54 ms) compared to healthy controls (972 ± 31 ms) and HFpEF (985 ± 32 ms). T2 relaxation times were elevated in HFmrEF (55.4 ± 3.4 ms) and HFrEF (56.0 ± 6.0 ms) compared to healthy controls (50.6 ± 2.1 ms). Differences in ECV did not reach statistical significance. HFmrEF differs from healthy controls and shares similarities with HFrEF in cardiac MRI parameters of fibrosis and inflammation. View Full-Text
Keywords: HFmrEF; T2 mapping; T1 mapping; ECV, fibrosis; inflammation; strain HFmrEF; T2 mapping; T1 mapping; ECV, fibrosis; inflammation; strain
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Doeblin, P.; Hashemi, D.; Tanacli, R.; Lapinskas, T.; Gebker, R.; Stehning, C.; Motzkus, L.A.; Blum, M.; Tahirovic, E.; Dordevic, A.; Kraft, R.; Zamani, S.M.; Pieske, B.; Edelmann, F.; Düngen, H.-D.; Kelle, S. CMR Tissue Characterization in Patients with HFmrEF. J. Clin. Med. 2019, 8, 1877.

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