Next Article in Journal
Monochorionic Twins: A Delicate Balance
Next Article in Special Issue
Acute Kidney Injury and Septic Shock—Defined by Updated Sepsis-3 Criteria in Critically Ill Patients
Previous Article in Journal
Factors Associated with Shortening of Prehospital Delay among Patients with Acute Ischemic Stroke
Previous Article in Special Issue
General Anesthetic Agents and Renal Function after Nephrectomy
Article

Acute Kidney Injury after Lung Transplantation: A Systematic Review and Meta-Analysis

1
Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, USA
2
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
3
Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
4
Department of Thoracic Medicine and Surgery, Temple University Hospital, Philadelphia, PA 19140, USA
5
Department of Internal Medicine, St. Agnes Hospital, Baltimore, MD 21229, USA
6
Department of Internal Medicine, University of Arizona, Tucson, AZ 85721, USA
7
Department of Medicine, Deaconess Health System, Evansville, IN 47747, USA
8
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, OH 44195, USA
9
Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA
10
Department of Medicine, Mayo Clinic, Jacksonville, FL 32224, USA
11
Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(10), 1713; https://doi.org/10.3390/jcm8101713
Received: 6 September 2019 / Revised: 3 October 2019 / Accepted: 15 October 2019 / Published: 17 October 2019
Background: Lung transplantation has been increasingly performed worldwide and is considered an effective therapy for patients with various causes of end-stage lung diseases. We performed a systematic review to assess the incidence and impact of acute kidney injury (AKI) and severe AKI requiring renal replacement therapy (RRT) in patients after lung transplantation. Methods: A literature search was conducted utilizing Ovid MEDLINE, EMBASE, and Cochrane Database from inception through June 2019. We included studies that evaluated the incidence of AKI, severe AKI requiring RRT, and mortality risk of AKI among patients after lung transplantation. Pooled incidence and odds ratios (ORs) with 95% confidence interval (CI) were obtained using random-effects meta-analysis. The protocol for this meta-analysis is registered with PROSPERO (International Prospective Register of Systematic Reviews; no. CRD42019134095). Results: A total of 26 cohort studies with a total of 40,592 patients after lung transplantation were enrolled. Overall, the pooled estimated incidence rates of AKI (by standard AKI definitions) and severe AKI requiring RRT following lung transplantation were 52.5% (95% CI: 45.8–59.1%) and 9.3% (95% CI: 7.6–11.4%). Meta-regression analysis demonstrated that the year of study did not significantly affect the incidence of AKI (p = 0.22) and severe AKI requiring RRT (p = 0.68). The pooled ORs of in-hospital mortality in patients after lung transplantation with AKI and severe AKI requiring RRT were 2.75 (95% CI, 1.18–6.41) and 10.89 (95% CI, 5.03–23.58). At five years, the pooled ORs of mortality among patients after lung transplantation with AKI and severe AKI requiring RRT were 1.47 (95% CI, 1.11–1.94) and 4.79 (95% CI, 3.58–6.40), respectively. Conclusion: The overall estimated incidence rates of AKI and severe AKI requiring RRT in patients after lung transplantation are 52.5% and 9.3%, respectively. Despite advances in therapy, the incidence of AKI in patients after lung transplantation does not seem to have decreased. In addition, AKI after lung transplantation is significantly associated with reduced short-term and long-term survival. View Full-Text
Keywords: acute kidney injury; incidence; lung transplantation; transplantation; epidemiology; meta-analysis acute kidney injury; incidence; lung transplantation; transplantation; epidemiology; meta-analysis
Show Figures

Figure 1

MDPI and ACS Style

Lertjitbanjong, P.; Thongprayoon, C.; Cheungpasitporn, W.; O’Corragain, O.A.; Srivali, N.; Bathini, T.; Watthanasuntorn, K.; Aeddula, N.R.; Salim, S.A.; Ungprasert, P.; Gillaspie, E.A.; Wijarnpreecha, K.; Mao, M.A.; Kaewput, W. Acute Kidney Injury after Lung Transplantation: A Systematic Review and Meta-Analysis. J. Clin. Med. 2019, 8, 1713. https://doi.org/10.3390/jcm8101713

AMA Style

Lertjitbanjong P, Thongprayoon C, Cheungpasitporn W, O’Corragain OA, Srivali N, Bathini T, Watthanasuntorn K, Aeddula NR, Salim SA, Ungprasert P, Gillaspie EA, Wijarnpreecha K, Mao MA, Kaewput W. Acute Kidney Injury after Lung Transplantation: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2019; 8(10):1713. https://doi.org/10.3390/jcm8101713

Chicago/Turabian Style

Lertjitbanjong, Ploypin, Charat Thongprayoon, Wisit Cheungpasitporn, Oisín A. O’Corragain, Narat Srivali, Tarun Bathini, Kanramon Watthanasuntorn, Narothama R. Aeddula, Sohail A. Salim, Patompong Ungprasert, Erin A. Gillaspie, Karn Wijarnpreecha, Michael A. Mao, and Wisit Kaewput. 2019. "Acute Kidney Injury after Lung Transplantation: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 8, no. 10: 1713. https://doi.org/10.3390/jcm8101713

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop