Next Article in Journal
Adalimumab Therapy Improves Intestinal Dysbiosis in Crohn’s Disease
Previous Article in Journal
A Combined Score of Circulating miRNAs Allows Outcome Prediction in Critically Ill Patients
Open AccessArticle

The Effectiveness of Intermittent Fasting to Reduce Body Mass Index and Glucose Metabolism: A Systematic Review and Meta-Analysis

1
Department of Endocrinology and Metabolism, Inha University School of Medicine, Incheon 22332, Korea
2
Graduate School, Yonsei University College of Medicine, Seoul 03722, Korea
3
Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Clin. Med. 2019, 8(10), 1645; https://doi.org/10.3390/jcm8101645
Received: 18 September 2019 / Revised: 1 October 2019 / Accepted: 7 October 2019 / Published: 9 October 2019
(This article belongs to the Section Endocrinology & Metabolism)
The effects of an intermittent fasting diet (IFD) in the general population are still controversial. In this study, we aimed to systematically evaluate the effectiveness of an IFD to reduce body mass index and glucose metabolism in the general population without diabetes mellitus. Cochrane, PubMed, and Embase databases were searched to identify randomized controlled trials and controlled clinical trials that compared an IFD with a regular diet or a continuous calorie restriction diet. The effectiveness of an IFD was estimated by the weighted mean difference (WMD) for several variables associated with glucometabolic parameters including body mass index (BMI) and fasting glucose. The pooled mean differences of outcomes were calculated using a random effects model. From 2814 studies identified through a literature search, we finally selected 12 articles (545 participants). Compared with a control diet, an IFD was associated with a significant decline in BMI (WMD, −0.75 kg/m2; 95% CI, −1.44 to −0.06), fasting glucose level (WMD, −4.16 mg/dL; 95% CI, −6.92 to −1.40), and homeostatic model assessment of insulin resistance (WMD, −0.54; 95% CI, −1.05 to −0.03). Fat mass (WMD, −0.98 kg; 95% CI, −2.32 to 0.36) tended to decrease in the IFD group with a significant increase in adiponectin (WMD, 1008.9 ng/mL; 95% CI, 140.5 to 1877.3) and a decrease in leptin (WMD, −0.51 ng/mL; 95% CI, −0.77 to −0.24) levels. An IFD may provide a significant metabolic benefit by improving glycemic control, insulin resistance, and adipokine concentration with a reduction of BMI in adults. View Full-Text
Keywords: intermittent fasting; glucose metabolism; insulin resistance; body mass index intermittent fasting; glucose metabolism; insulin resistance; body mass index
Show Figures

Figure 1

MDPI and ACS Style

Cho, Y.; Hong, N.; Kim, K.-W.; Cho, S.J.; Lee, M.; Lee, Y.-H.; Lee, Y.-H.; Kang, E.S.; Cha, B.-S.; Lee, B.-W. The Effectiveness of Intermittent Fasting to Reduce Body Mass Index and Glucose Metabolism: A Systematic Review and Meta-Analysis. J. Clin. Med. 2019, 8, 1645.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop