Next Article in Journal
Magnetic Resonance Imaging and Interictal Electroencephalography Findings in Newly Diagnosed Epileptic Children
Previous Article in Journal
The Role of Sex in Memory Function: Considerations and Recommendations in the Context of Exercise
Open AccessArticle

Patterns of Occurrence and Outcomes of Contralateral Breast Cancer: Analysis of SEER Data

1
Department of Breast Surgery, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510030, China
2
State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510030, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work and share the first authorship.
J. Clin. Med. 2018, 7(6), 133; https://doi.org/10.3390/jcm7060133
Received: 15 April 2018 / Revised: 16 May 2018 / Accepted: 28 May 2018 / Published: 31 May 2018
(This article belongs to the Section Oncology)
Population-based estimates are lacking for the temporal trends in the contralateral breast cancer (CBC) risk for patients with breast cancer (BC). Data for BC patients diagnosed with CBC were collected from the Surveillance, Epidemiology, and End Results database. CBC incidence was calculated using the Kaplan-Meier method and the temporal trend in CBC incidence was assessed using joinpoint regression. Survival analysis was calculated using propensity scoring (PS) and multivariate Cox regression with a competing risk model. We found that 10,944 of 212,630 patients with early-stage BC were subsequently diagnosed with secondary BC in the contralateral breast. The 5-, 10-, 15-, and 20-year cumulative CBC incidences were 1.9, 4.6, 7.6, and 10.5%, respectively. Being younger (<40 years), black, hormone receptor-negative, and having undergone radiotherapy were correlated with a high risk of CBC occurrence. CBC incidence increased continuously in the first 11 years after the initial cancer diagnosis, and the upward trend slowed from years 11 to 21, and tended to decline from years 21 to 24. CBC diagnosis was significantly and negatively associated with survival. We reported population-based estimates of the CBC occurrence pattern and risk factors. Patients are at high risk of developing CBC in the first 21 years after the initial BC diagnosis. View Full-Text
Keywords: contralateral breast cancer; incidence; outcome; SEER; propensity score contralateral breast cancer; incidence; outcome; SEER; propensity score
Show Figures

Figure 1

MDPI and ACS Style

Xiong, Z.; Yang, L.; Deng, G.; Huang, X.; Li, X.; Xie, X.; Wang, J.; Shuang, Z.; Wang, X. Patterns of Occurrence and Outcomes of Contralateral Breast Cancer: Analysis of SEER Data. J. Clin. Med. 2018, 7, 133.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop