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Open AccessArticle

A New Inflammatory Marker: Elevated Monocyte to HDL Cholesterol Ratio Associated with Smoking

Department of Cardiology, Elazığ Education and Research Hospital, Elazığ 23200, Turkey
Department of Cardiology, Elazığ Medical Park Hospital (Affiliated to Istinye University), Elazığ 23040, Turkey
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(4), 76;
Received: 4 March 2018 / Revised: 2 April 2018 / Accepted: 6 April 2018 / Published: 10 April 2018
(This article belongs to the Section Molecular Medicine)
Objectives: The adverse effects of smoking in various pathologies are mediated by its effects on the inflammatory system. The monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) has recently emerged as an indicator of inflammation. We aimed to investigate the relationship between MHR and cigarette smoking. Patients and Methods: Three hundred and ninety seven consecutive participants who smoke and 515 healthy subjects with no history of smoking enrolled in the study. Complete blood count parameters and lipid profile were analyzed in all study participants. Smoking habits were calculated as pack.years and number of cigarettes smoked per day. Results: MHR levels were significantly higher in smokers compared to non-smokers (respectively, 15.71 (12.02–20.00) and 11.17 (8.50–14.16), p < 0.0001)). Pearson’s correlation analysis revealed a weak but positive correlation between pack.year and MHR in the smokers group, and there was a moderate positive correlation between the number of cigarettes smoked daily and MHR in the group. In receiver operating characteristics (ROC) analyses, it was determined that a MHR value >13.00 measured in smoker participants at application had a predictive specificity of 66.6% and sensitivity of 70.0% for smoking (area under the curve [AUC] 0.729, 95% CI 0.696, 0.762; p < 0.0001). Conclusions: Elevated MHR is associated with cigarette smoking and may be a useful indicator of a systemic inflammatory response in smokers. Smoker participants who have high MHR levels can easily be identified during routine complete blood count (CBC) analysis and could possibly benefit from preventive treatment. View Full-Text
Keywords: smoking; monocyte to high-density lipoprotein cholesterol; inflammation smoking; monocyte to high-density lipoprotein cholesterol; inflammation
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Yılmaz, M.; Kayançiçek, H. A New Inflammatory Marker: Elevated Monocyte to HDL Cholesterol Ratio Associated with Smoking. J. Clin. Med. 2018, 7, 76.

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