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EMT in Breast Carcinoma—A Review

1
Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada
2
Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Jane Grant-Kels
J. Clin. Med. 2016, 5(7), 65; https://doi.org/10.3390/jcm5070065
Received: 21 November 2015 / Revised: 1 July 2016 / Accepted: 6 July 2016 / Published: 14 July 2016
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
The epithelial to mesenchymal transition (EMT) is a cellular program that is involved in embryonic development; wound healing, but also in tumorigenesis. Breast carcinoma (BC) is the most common cancer in women worldwide, and the majority of deaths (90%) are caused by invasion and metastasis. The EMT plays an important role in invasion and subsequent metastasis. Several distinct biological events integrate a cascade that leads not only to a change from an epithelial to mesenchymal phenotype, but allows for detachment, migration, invasion and ultimately, colonization of a second site. Understanding the biological intricacies of the EMT may provide important insights that lead to the development of therapeutic targets in pre-invasive and invasive breast cancer, and could be used as biomarkers identifying tumor subsets with greater chances of recurrence, metastasis and therapeutic resistance leading to death. View Full-Text
Keywords: EMT; breast; cancer; invasion; metastasis EMT; breast; cancer; invasion; metastasis
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Felipe Lima, J.; Nofech-Mozes, S.; Bayani, J.; Bartlett, J.M.S. EMT in Breast Carcinoma—A Review. J. Clin. Med. 2016, 5, 65.

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