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EMT in Breast Carcinoma—A Review

Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada
Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada
Author to whom correspondence should be addressed.
Academic Editor: Jane Grant-Kels
J. Clin. Med. 2016, 5(7), 65;
Received: 21 November 2015 / Revised: 1 July 2016 / Accepted: 6 July 2016 / Published: 14 July 2016
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
The epithelial to mesenchymal transition (EMT) is a cellular program that is involved in embryonic development; wound healing, but also in tumorigenesis. Breast carcinoma (BC) is the most common cancer in women worldwide, and the majority of deaths (90%) are caused by invasion and metastasis. The EMT plays an important role in invasion and subsequent metastasis. Several distinct biological events integrate a cascade that leads not only to a change from an epithelial to mesenchymal phenotype, but allows for detachment, migration, invasion and ultimately, colonization of a second site. Understanding the biological intricacies of the EMT may provide important insights that lead to the development of therapeutic targets in pre-invasive and invasive breast cancer, and could be used as biomarkers identifying tumor subsets with greater chances of recurrence, metastasis and therapeutic resistance leading to death. View Full-Text
Keywords: EMT; breast; cancer; invasion; metastasis EMT; breast; cancer; invasion; metastasis
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Felipe Lima, J.; Nofech-Mozes, S.; Bayani, J.; Bartlett, J.M.S. EMT in Breast Carcinoma—A Review. J. Clin. Med. 2016, 5, 65.

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