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Treatment and Prevention of Bleeds in Haemophilia Patients with Inhibitors to Factor VIII/IX
Open AccessFeature PaperReview

Hemophilia Care in the Pediatric Age

Thrombosis and Hemostasis Unit, Regional Reference Center for Hemorrhagic Diseases, Giannina Gaslini Children’s Hospital, 16147 Genova, Italy
Hematology Unit, Giannina Gaslini Children’s Hospital, 16147 Genova, Italy
Author to whom correspondence should be addressed.
Academic Editors: Massimo Morfini and Giovanni Di Minno
J. Clin. Med. 2017, 6(5), 54;
Received: 31 January 2017 / Revised: 12 May 2017 / Accepted: 16 May 2017 / Published: 19 May 2017
(This article belongs to the Special Issue Outstanding Advances in Hemophilia Therapies)
Hemophilia is the most common of the severe bleeding disorders and if not properly managed since early infancy can lead to chronic disease and lifelong disabilities. However, it enjoys the most efficacious and safe treatment among the most prevalent monogenic disorders. Hemophilia should be considered in the neonatal period in the case of unusual bleeding or in the case of positive family history. Later, hemophilia should be suspected mainly in males because of abnormal bruising/bleeding or unusual bleeding following invasive procedures—for example, tonsillectomy or circumcision. Prophylactic treatment that is started early with clotting-factor concentrates has been shown to prevent hemophilic arthropathy and is, therefore, the gold standard of care for hemophilia A and B in most countries with adequate resources. Central venous access catheters and arterovenous fistulas play an important role in the management of hemophilia children requiring repeated and/or urgent administration of coagulation factor concentrates. During childhood and adolescence, personalized treatment strategies that suit the patient and his lifestyle are essential to ensure optimal outcomes. Physical activity is important and can contribute to better coordination, endurance, flexibility and strength. The present article focuses also on questions frequently posed to pediatric hematologists like vaccinations, day-care/school access and dental care. View Full-Text
Keywords: hemophilia; neonate; child; treatment; prophylaxis; vaccinations; sport; psychology; venous access hemophilia; neonate; child; treatment; prophylaxis; vaccinations; sport; psychology; venous access
MDPI and ACS Style

Bertamino, M.; Riccardi, F.; Banov, L.; Svahn, J.; Molinari, A.C. Hemophilia Care in the Pediatric Age. J. Clin. Med. 2017, 6, 54.

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