Next Article in Journal / Special Issue
CVD and Oxidative Stress
Previous Article in Journal
Telehealth: Increasing Access to High Quality Care by Expanding the Role of Technology in Correctional Medicine
Previous Article in Special Issue
The Effects of Ascorbate, N-Acetylcysteine, and Resveratrol on Fibroblasts from Patients with Mitochondrial Disorders
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessFeature PaperReview
J. Clin. Med. 2017, 6(2), 21;

Oxidative Stress in COPD: Sources, Markers, and Potential Mechanisms

Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK
Author to whom correspondence should be addressed.
Academic Editor: Francisco Dasí
Received: 16 December 2016 / Revised: 1 February 2017 / Accepted: 5 February 2017 / Published: 15 February 2017
(This article belongs to the Special Issue The Role of Oxidant Stress in Disease)
Full-Text   |   PDF [1203 KB, uploaded 15 February 2017]   |  


Markers of oxidative stress are increased in chronic obstructive pulmonary disease (COPD) and reactive oxygen species (ROS) are able to alter biological molecules, signaling pathways and antioxidant molecule function, many of which have been implicated in the pathogenesis of COPD. However, the involvement of ROS in the development and progression of COPD is not proven. Here, we discuss the sources of ROS, and the defences that have evolved to protect against their harmful effects. We address the role that ROS may have in the development and progression of COPD, as well as current therapeutic attempts at limiting the damage they cause. Evidence has indicated that the function of several key cells appears altered in COPD patients, and expression levels of important oxidant and antioxidant molecules may be abnormal. Therapeutic trials attempting to restore equilibrium to these molecules have not impacted upon all facets of disease and whilst the theory behind ROS influence in COPD appears sound, current models testing relevant pathways to tissue damage are limited. The heterogeneity seen in COPD patients presents a challenge to our understanding, and further research is essential to identify potential targets and stratified COPD patient populations where ROS therapies may be maximally efficacious. View Full-Text
Keywords: COPD; oxidative stress; neutrophil; macrophage; antioxidant; antiproteinase; mechanisms; therapeutic studies COPD; oxidative stress; neutrophil; macrophage; antioxidant; antiproteinase; mechanisms; therapeutic studies

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

McGuinness, A.J.A.; Sapey, E. Oxidative Stress in COPD: Sources, Markers, and Potential Mechanisms. J. Clin. Med. 2017, 6, 21.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top