Next Article in Journal / Special Issue
Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes
Previous Article in Journal / Special Issue
Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion
 
 
Article

Role of the Slug Transcription Factor in Chemically-Induced Skin Cancer

1
Department of Epigenetics and Molecular Carcinogenesis, University of Texas M.D. Anderson Cancer Center, P.O. Box 389, Smithville, TX 78957, USA
2
Program in Toxicology and Pharmacology, College of Pharmacy, University of New Mexico Health Sciences Center, MSC 09 5360, 1 University of New Mexico, Albuquerque, NM 87131, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: David A. Brenner, Tatiana Kisseleva and Jonas Fuxe
J. Clin. Med. 2016, 5(2), 21; https://doi.org/10.3390/jcm5020021
Received: 12 November 2015 / Revised: 15 January 2016 / Accepted: 25 January 2016 / Published: 3 February 2016
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
The Slug transcription factor plays an important role in ultraviolet radiation (UVR)-induced skin carcinogenesis, particularly in the epithelial-mesenchymal transition (EMT) occurring during tumor progression. In the present studies, we investigated the role of Slug in two-stage chemical skin carcinogenesis. Slug and the related transcription factor Snail were expressed at high levels in skin tumors induced by 7,12-dimethylbenz[α]anthracene application followed by 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment. TPA-induced transient elevation of Slug and Snail proteins in normal mouse epidermis and studies in Slug transgenic mice indicated that Slug modulates TPA-induced epidermal hyperplasia and cutaneous inflammation. Although Snail family factors have been linked to inflammation via interactions with the cyclooxygenase-2 (COX-2) pathway, a pathway that also plays an important role in skin carcinogenesis, transient TPA induction of Slug and Snail appeared unrelated to COX-2 expression. In cultured human keratinocytes, TPA induced Snail mRNA expression while suppressing Slug expression, and this differential regulation was due specifically to activation of the TPA receptor. These studies show that Slug and Snail exhibit similar patterns of expression during both UVR and chemical skin carcinogenesis, that Slug and Snail can be differentially regulated under some conditions and that in vitro findings may not recapitulate in vivo results. View Full-Text
Keywords: slug; snail; epithelial-mesenchymal transition; skin carcinogenesis slug; snail; epithelial-mesenchymal transition; skin carcinogenesis
Show Figures

Figure 1

MDPI and ACS Style

Von Maltzan, K.; Li, Y.; Rundhaug, J.E.; Hudson, L.G.; Fischer, S.M.; Kusewitt, D.F. Role of the Slug Transcription Factor in Chemically-Induced Skin Cancer. J. Clin. Med. 2016, 5, 21. https://doi.org/10.3390/jcm5020021

AMA Style

Von Maltzan K, Li Y, Rundhaug JE, Hudson LG, Fischer SM, Kusewitt DF. Role of the Slug Transcription Factor in Chemically-Induced Skin Cancer. Journal of Clinical Medicine. 2016; 5(2):21. https://doi.org/10.3390/jcm5020021

Chicago/Turabian Style

Von Maltzan, Kristine, Yafan Li, Joyce E. Rundhaug, Laurie G. Hudson, Susan M. Fischer, and Donna F. Kusewitt. 2016. "Role of the Slug Transcription Factor in Chemically-Induced Skin Cancer" Journal of Clinical Medicine 5, no. 2: 21. https://doi.org/10.3390/jcm5020021

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop