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J. Clin. Med. 2016, 5(11), 97;

An Age-Related Morphometric Profile of Skeletal Muscle in Healthy Untrained Women

First Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Vass. Sofias Ave. 72–74, Athens 11528, Greece
Author to whom correspondence should be addressed.
Academic Editor: Emmanuel Andrès
Received: 11 August 2016 / Revised: 1 November 2016 / Accepted: 3 November 2016 / Published: 7 November 2016
Full-Text   |   PDF [198 KB, uploaded 7 November 2016]


There is a paucity of data on muscle biopsies in females of mixed ages in terms of age-related changes. Cross sections of autopsy material including the quadriceps femoris and biceps brachii muscles were obtained from 23 healthy women, aged 24–82 years, who had suffered sudden death. We calculated the percentage of the number, and the mean diameter, of type I and type II muscle fibers within the fascicles as well as in their peripheral parts. The number of type II fibers were shown to reduce significantly with age (p < 0.005), especially in the fascicle periphery, but the percentage of type 1 fibers did not alter significantly. It was noted that type II fibers diminished in size with age, indicating a relationship between fiber size and age. This result became more apparent in the fascicle periphery (p < 0.05). In women, type II muscle fibers were seen to reduce in size and number with advancing age. We postulate that regular physical activity can increase the size of type II muscle fibers, thus helping to both prevent and treat age-related muscle loss. View Full-Text
Keywords: morphometry; histochemistry; muscle biopsy; fiber type; aging morphometry; histochemistry; muscle biopsy; fiber type; aging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Bougea, A.; Papadimas, G.; Papadopoulos, C.; Paraskevas, G.P.; Kalfakis, N.; Manta, P.; Kararizou, E. An Age-Related Morphometric Profile of Skeletal Muscle in Healthy Untrained Women. J. Clin. Med. 2016, 5, 97.

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J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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