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J. Clin. Med. 2016, 5(10), 87;

Multiple Roles for B-Lymphocytes in Sjogren’s Syndrome

Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine, 100 High Street, Buffalo, NY 14203, USA
Immco Diagnostics and the Department of Oral Diagnostic Sciences, SUNY at Buffalo School of Dental Science, Buffalo, NY 14203, USA
College of Veterinary Medicine University of Florida, Gainesville, FL 32608, USA
Author to whom correspondence should be addressed.
Academic Editor: Bonnie N. Dittel
Received: 17 August 2016 / Revised: 28 September 2016 / Accepted: 29 September 2016 / Published: 8 October 2016
(This article belongs to the Special Issue B Cells in Autoimmunity)
Full-Text   |   PDF [201 KB, uploaded 8 October 2016]


Sjogren’s syndrome (SS) is a complex heterogeneous autoimmune disease resulting in loss of salivary gland and lacrimal gland function that may include multiple systemic manifestations including lymphoma. Multiple cell types participate in disease pathogenesis. This review discusses evidence for abnormal B cell subpopulations in patients with SS, critical roles of B cells in SS and the status of B cell–directed therapies in the management of patients with SS. View Full-Text
Keywords: Sjogren’s syndrome; B cells; marginal zone B cells Sjogren’s syndrome; B cells; marginal zone B cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ambrus, J.L.; Suresh, L.; Peck, A. Multiple Roles for B-Lymphocytes in Sjogren’s Syndrome. J. Clin. Med. 2016, 5, 87.

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