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Exploring miRNA-Associated Signatures with Diagnostic Relevance in Glioblastoma Multiforme and Breast Cancer Patients

Department of Chemistry and Biochemistry, Université de Moncton, 18 Antonine-Maillet avenue, Moncton, NB E1A 3E9, Canada
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Academic Editors: Takahiro Ochiya and Ryou-u Takahashi
J. Clin. Med. 2015, 4(8), 1612-1630; https://doi.org/10.3390/jcm4081612
Received: 30 June 2015 / Revised: 23 July 2015 / Accepted: 4 August 2015 / Published: 14 August 2015
(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers)
The growing attention that non-coding RNAs have attracted in the field of cancer research in recent years is undeniable. Whether investigated as prospective therapeutic targets or prognostic indicators or diagnostic biomarkers, the clinical relevance of these molecules is starting to emerge. In addition, identification of non-coding RNAs in a plethora of body fluids has further positioned these molecules as attractive non-invasive biomarkers. This review will first provide an overview of the synthetic cascade that leads to the production of the small non-coding RNAs microRNAs (miRNAs) and presents their strengths as biomarkers of disease. Our interest will next be directed at exploring the diagnostic utility of miRNAs in two types of cancer: the brain tumor glioblastoma multiforme (GBM) and breast cancer. Finally, we will discuss additional clinical implications associated with miRNA detection as well as introduce other non-coding RNAs that have generated recent interest in the cancer research community. View Full-Text
Keywords: microRNAs; glioma; glioblastoma multiforme; breast cancer; cancer diagnosis; cancer therapeutics; non-coding RNAs; long non-coding RNAs microRNAs; glioma; glioblastoma multiforme; breast cancer; cancer diagnosis; cancer therapeutics; non-coding RNAs; long non-coding RNAs
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LeBlanc, V.C.; Morin, P., Jr. Exploring miRNA-Associated Signatures with Diagnostic Relevance in Glioblastoma Multiforme and Breast Cancer Patients. J. Clin. Med. 2015, 4, 1612-1630.

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