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Role of MicroRNAs-221/222 in Digestive Systems

Center for Preventive Medicine, Keio University Hospital, Tokyo 160-0016, Japan
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Author to whom correspondence should be addressed.
Academic Editors: Takahiro Ochiya and Ryou-u Takahashi
J. Clin. Med. 2015, 4(8), 1566-1577;
Received: 29 June 2015 / Revised: 17 July 2015 / Accepted: 22 July 2015 / Published: 6 August 2015
(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers)
MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors, such as esophageal adenocarcinoma, gastric adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and pancreatic ductal adenocarcinoma. In these cancers, silencing miR-221/222 could represent a novel anti-tumor approach to inhibit tumor growth and metastasis. On the other hand, miR-221/222 also play onco-suppressive roles in cholangiocarcinoma and gastrointestinal stromal tumors (GISTs). Here we will review the roles of miR-221/222 in digestive systems and their possibility as prognostic and therapeutic tools. View Full-Text
Keywords: microRNA; colorectal cancer; hepatocellular carcinoma; pancreatic cancer microRNA; colorectal cancer; hepatocellular carcinoma; pancreatic cancer
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Matsuzaki, J.; Suzuki, H. Role of MicroRNAs-221/222 in Digestive Systems. J. Clin. Med. 2015, 4, 1566-1577.

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