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Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?

1
Clinical Neurosciences Research Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK
2
Eye Unit, University Southampton NHS Trust, Southampton SO16 6YD, UK
3
Genomic Informatics, Human Genetics & Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2014, 3(4), 1234-1257; https://doi.org/10.3390/jcm3041234
Received: 4 August 2014 / Revised: 20 October 2014 / Accepted: 22 October 2014 / Published: 3 November 2014
(This article belongs to the Special Issue Age-Related Macular Disease)
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in developed countries. The role of complement in the development of AMD is now well-established. While some studies show evidence of complement dysregulation within the eye, others have demonstrated elevated systemic complement activation in association with AMD. It is unclear which one is the primary driver of disease. This has important implications for designing novel complement-based AMD therapies. We present a summary of the current literature and suggest that intraocular rather than systemic modulation of complement may prove more effective. View Full-Text
Keywords: age-related macular degeneration; complement pathway; complement system proteins/genetics; pathway analysis; proteomics age-related macular degeneration; complement pathway; complement system proteins/genetics; pathway analysis; proteomics
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Warwick, A.; Khandhadia, S.; Ennis, S.; Lotery, A. Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation? J. Clin. Med. 2014, 3, 1234-1257.

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