Next Article in Journal
Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?
Next Article in Special Issue
Physiopathological, Epidemiological, Clinical and Therapeutic Aspects of Exercise-Associated Hyponatremia
Previous Article in Journal / Special Issue
Incidence, Etiology and Outcomes of Hyponatremia after Transsphenoidal Surgery: Experience with 344 Consecutive Patients at a Single Tertiary Center
Open AccessArticle

Hyponatraemia in Emergency Medical Admissions—Outcomes and Costs

Department of Internal Medicine, St James's Hospital, Dublin 8, Ireland
Author to whom correspondence should be addressed.
J. Clin. Med. 2014, 3(4), 1220-1233;
Received: 16 August 2014 / Revised: 6 October 2014 / Accepted: 10 October 2014 / Published: 29 October 2014
(This article belongs to the Special Issue Hyponatremia: Advances in Diagnosis and Management)
Healthcare systems in the developed world are struggling with the demand of emergency room presentations; the study of the factors driving such demand is of fundamental importance. From a database of all emergency medical admissions (66,933 episodes in 36,271 patients) to St James’ Hospital, Dublin, Ireland, over 12 years (2002 to 2013) we have explored the impact of hyponatraemia on outcomes (30 days in-hospital mortality, length of stay (LOS) and costs). Identified variables, including Acute Illness Severity, Charlson Co-Morbidity and Chronic Disabling Disease that proved predictive univariately were entered into a multivariable logistic regression model to predict the bivariate of 30 days in-hospital survival. A zero truncated Poisson regression model assessed LOS and episode costs and the incidence rate ratios were calculated. Hyponatraemia was present in 22.7% of episodes and 20.3% of patients. The 30 days in-hospital mortality rate for hyponatraemic patients was higher (15.9% vs. 6.9% p < 0.001) and the LOS longer (6.3 (95% CI 2.9, 12.2) vs. 4.0 (95% CI 1.5, 8.2) p < 0.001). Both parameters worsened with the severity of the initial sodium level. Hospital costs increased non-linearly with the severity of initial hyponatraemia. Hyponatraemia remained an independent predictor of 30 days in-hospital mortality, length of stay and costs in the multi-variable model. View Full-Text
Keywords: hyponatraemia; mortality; length of stay; emergency admission hyponatraemia; mortality; length of stay; emergency admission
Show Figures

Graphical abstract

MDPI and ACS Style

Conway, R.; Byrne, D.; O'Riordan, D.; Silke, B. Hyponatraemia in Emergency Medical Admissions—Outcomes and Costs. J. Clin. Med. 2014, 3, 1220-1233.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop