Nationwide Comparison of ICU Procedure Frequencies in Japan Using a Public Open Database: A Cross-Sectional Study by ICU Admission Fee Type and Region
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Data Sources
2.2. Eligibility Criteria
2.3. Variables
- Metropolitan: areas with a population density ≥ 1000 persons/km2 or a total population ≥ 1,000,000;
- Suburban: areas with a population density of 200–1000 persons/km2 or a total population ≥ 300,000;
- Rural: areas with a population density of <200 persons/km2 and a total population < 300,000.
2.4. Statistical Analyses
2.4.1. Descriptive Analysis and Comparison of Categorical Variables
2.4.2. Primary Analysis: Assessment of Regional Differences Using Poisson Regression
2.4.3. Group Analyses
2.4.4. Use of Generative Artificial Intelligence
3. Results
3.1. Characteristics
3.2. ICU Procedure Rate
3.3. Group Analysis
3.4. Sensitivity Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
| AL | Arterial line placement |
| CI | Confidence interval |
| CRRT | Continuous renal replacement therapy |
| CVC | Central venous catheter insertion |
| DPC | Diagnosis Procedure Combination |
| ICU | Intensive care unit |
| JIPAD | Japanese Intensive Care Patient Database |
| MV | Mechanical ventilation |
| PICU | Pediatric intensive care unit |
| RR | Rate ratio |
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| Secondary Medical Area | |||
|---|---|---|---|
| Metropolitan | Suburban | Rural | |
| Population (millions) a | 57.5 | 57.3 | 11.4 |
| Area (km2) a | 18,617 | 180,963 | 173,379 |
| Population density (/km2) | 3088.6 | 315.0 | 65.8 |
| Number of medical doctors a | 116,068 | 109,844 | 92,755 |
| Density of medical doctors (/km2) | 6.23 | 0.61 | 0.10 |
| Number of hospitals a | 2861 | 4201 | 1143 |
| Number of ICUs according to different admission fee types b | |||
| High acuity ICU (n = 248) | 133 | 112 | 3 |
| Standard ICU (n = 354) | 166 | 166 | 22 |
| p < 0.01 | |||
| Median [Interquartile Range] | ||||
|---|---|---|---|---|
| AL | CVC | MV | CRRT | |
| All | 0.81 [0.64–0.91] | 0.27 [0.17–0.40] | 0.26 [0.17–0.37] | 0.08 [0.05–0.11] |
| High acuity ICU | 0.87 [0.75–0.93] | 0.33 [0.22–0.45] | 0.33 [0.22–0.42] | 0.08 [0.06–0.11] |
| Standard ICU | 0.76 [0.56–0.87] | 0.23 [0.16–0.36] | 0.22 [0.15–0.32] | 0.08 [0.05–0.12] |
| Metropolitan | 0.80 [0.55–0.90] | 0.26 [0.17–0.39] | 0.24 [0.15–0.37] | 0.07 [0.05–0.11] |
| non-metropolitan | 0.82 [0.70–0.91] | 0.28 [0.17–0.41] | 0.27 [0.18–0.37] | 0.08 [0.06–0.12] |
| Rate Ratio [95% CI] | |||
|---|---|---|---|
| Imputed Value 1 | Imputed Value 5 | Imputed Value 9 | |
| Metropolitan vs. non-metropolitan | |||
| AL | 1.093 [1.023–1.167] | 1.090 [1.024–1.161] | 1.087 [1.024–1.155] |
| CVC | 1.095 [0.973–1.233] | 1.095 [0.995–1.205] | 1.095 [1.008–1.189] |
| MV | 1.124 [1.005–1.257] | 1.112 [1.019–1.213] | 1.103 [1.022–1.189] |
| CRRT | 1.395 [1.170–1.664] | 1.205 [1.089–1.333] | 1.177 [1.066–1.299] |
| High-acuity ICU vs. standard ICU | |||
| AL | 0.854 [0.799–0.912] | 0.861 [0.809–0.917] | 0.869 [0.818–0.923] |
| CVC | 0.684 [0.607–0.771] | 0.784 [0.712–0.863] | 0.875 [0.806–0.951] |
| MV | 0.619 [0.552–0.694] | 0.743 [0.681–0.811] | 0.857 [0.794–0.924] |
| CRRT | 0.626 [0.524–0.748] | 0.945 [0.854–1.046] | 1.010 [0.915–1.115] |
| Group analysis | |||
| High-acuity ICU (metropolitan vs. non-metropolitan) | |||
| AL | 1.065 [0.968–1.171] | 1.062 [0.968–1.165] | 1.059 [0.968–1.158] |
| CVC | 1.010 [0.870–1.174] | 1.011 [0.885–1.156] | 1.012 [0.895–1.145] |
| MV | 1.069 [0.936–1.220] | 1.064 [0.945–1.197] | 1.059 [0.949–1.182] |
| CRRT | 1.359 [1.018–1.814] | 1.117 [0.969–1.287] | 1.074 [0.936–1.232] |
| Standard ICU (metropolitan vs. non-metropolitan) | |||
| AL | 1.121 [1.028–1.222] | 1.121 [1.028–1.222] | 1.118 [1.031–1.213] |
| CVC | 1.203 [1.049–1.380] | 1.203 [1.049–1.380] | 1.191 [1.064–1.332] |
| MV | 1.176 [1.033–1.338] | 1.176 [1.033–1.338] | 1.152 [1.037–1.281] |
| CRRT | 1.300 [1.125–1.500] | 1.300 [1.125–1.500] | 1.281 [1.113–1.475] |
| Metropolitan (high-acuity ICU vs. standard ICU) | |||
| AL | 0.831 [0.748–0.922] | 0.838 [0.759–0.926] | 0.846 [0.769–0.930] |
| CVC | 0.621 [0.521–0.741] | 0.718 [0.623–0.827] | 0.807 [0.714–0.912] |
| MV | 0.580 [0.490–0.688] | 0.706 [0.620–0.804] | 0.821 [0.734–0.918] |
| CRRT | 0.603 [0.484–0.753] | 0.873 [0.757–1.007] | 0.922 [0.800–1.062] |
| Non-metropolitan (high-acuity ICU vs. standard ICU) | |||
| AL | 0.877 [0.809–0.951] | 0.885 [0.820–0.956] | 0.893 [0.830–0.961] |
| CVC | 0.751 [0.638–0.884] | 0.854 [0.751–0.972] | 0.949 [0.850–1.060] |
| MV | 0.658 [0.565–0.767] | 0.780 [0.693–0.878] | 0.893 [0.806–0.990] |
| CRRT | 0.644 [0.491–0.846] | 1.016 [0.881–1.171] | 1.100 [0.958–1.263] |
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Kawamura, Y.; Tanaka, A.; Nagata, O.; Matsuki, Y. Nationwide Comparison of ICU Procedure Frequencies in Japan Using a Public Open Database: A Cross-Sectional Study by ICU Admission Fee Type and Region. J. Clin. Med. 2026, 15, 2341. https://doi.org/10.3390/jcm15062341
Kawamura Y, Tanaka A, Nagata O, Matsuki Y. Nationwide Comparison of ICU Procedure Frequencies in Japan Using a Public Open Database: A Cross-Sectional Study by ICU Admission Fee Type and Region. Journal of Clinical Medicine. 2026; 15(6):2341. https://doi.org/10.3390/jcm15062341
Chicago/Turabian StyleKawamura, Yuko, Aiko Tanaka, Osamu Nagata, and Yuka Matsuki. 2026. "Nationwide Comparison of ICU Procedure Frequencies in Japan Using a Public Open Database: A Cross-Sectional Study by ICU Admission Fee Type and Region" Journal of Clinical Medicine 15, no. 6: 2341. https://doi.org/10.3390/jcm15062341
APA StyleKawamura, Y., Tanaka, A., Nagata, O., & Matsuki, Y. (2026). Nationwide Comparison of ICU Procedure Frequencies in Japan Using a Public Open Database: A Cross-Sectional Study by ICU Admission Fee Type and Region. Journal of Clinical Medicine, 15(6), 2341. https://doi.org/10.3390/jcm15062341

