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Volume 15
Issue 3
10.3390/jcm15031172
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Association Between Mitral Annular Calcification and Ventricular Tachycardia in Patients with Reduced and Mildly Reduced Ejection Fraction

by
Müjgan Ayşenur Şahin
,
Ahmet Seyda Yılmaz
*,
Elif Ergül
,
Hakan Duman
,
Hüseyin Durak
,
Abuzer Duran
,
Şuayp Osmanoğlu
and
Mustafa Çetin
Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize 53020, Türkiye
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2026, 15(3), 1172; https://doi.org/10.3390/jcm15031172
Submission received: 11 January 2026 / Revised: 25 January 2026 / Accepted: 30 January 2026 / Published: 2 February 2026
(This article belongs to the Special Issue Heart Failure: Treatment and Clinical Perspectives)
Versions Notes

Abstract

Objective: This study aimed to evaluate the association between mitral annular calcification (MAC) and ventricular tachycardia (VT) in patients with reduced and mildly reduced ejection fraction and to identify independent predictors of VT. Materials and Methods: A total of 143 patients with heart failure and left ventricular ejection fraction (LVEF) under 50% were included in this retrospective cross-sectional study. Patients were classified into two groups according to the presence of VT. Clinical, biochemical, and echocardiographic variables were compared between groups. Independent predictors of VT were identified using multivariable logistic regression analysis. Results: MAC was significantly more prevalent in the VT group compared with controls (43.6% vs. 17.4%, p < 0.001) and was the strongest independent predictor of VT (OR: 2.74; 95% CI: 1.13–6.65; p = 0.026). Higher inflammatory activity, lower serum albumin levels, increased left atrial volume, renal dysfunction, and elevated diastolic filling pressures were also associated with VT. Conclusion: MAC is a strong and independent predictor of ventricular tachycardia in patients with reduced and mildly reduced ejection fraction. Incorporating MAC into the overall arrhythmic risk profile alongside inflammatory, metabolic, and structural parameters may improve risk stratification in this population.
Keywords: heart failure; mitral annular calcification; ventricular tachycardia; arrhythmia; inflammation heart failure; mitral annular calcification; ventricular tachycardia; arrhythmia; inflammation

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MDPI and ACS Style

Şahin, M.A.; Yılmaz, A.S.; Ergül, E.; Duman, H.; Durak, H.; Duran, A.; Osmanoğlu, Ş.; Çetin, M. Association Between Mitral Annular Calcification and Ventricular Tachycardia in Patients with Reduced and Mildly Reduced Ejection Fraction. J. Clin. Med. 2026, 15, 1172. https://doi.org/10.3390/jcm15031172

AMA Style

Şahin MA, Yılmaz AS, Ergül E, Duman H, Durak H, Duran A, Osmanoğlu Ş, Çetin M. Association Between Mitral Annular Calcification and Ventricular Tachycardia in Patients with Reduced and Mildly Reduced Ejection Fraction. Journal of Clinical Medicine. 2026; 15(3):1172. https://doi.org/10.3390/jcm15031172

Chicago/Turabian Style

Şahin, Müjgan Ayşenur, Ahmet Seyda Yılmaz, Elif Ergül, Hakan Duman, Hüseyin Durak, Abuzer Duran, Şuayp Osmanoğlu, and Mustafa Çetin. 2026. "Association Between Mitral Annular Calcification and Ventricular Tachycardia in Patients with Reduced and Mildly Reduced Ejection Fraction" Journal of Clinical Medicine 15, no. 3: 1172. https://doi.org/10.3390/jcm15031172

APA Style

Şahin, M. A., Yılmaz, A. S., Ergül, E., Duman, H., Durak, H., Duran, A., Osmanoğlu, Ş., & Çetin, M. (2026). Association Between Mitral Annular Calcification and Ventricular Tachycardia in Patients with Reduced and Mildly Reduced Ejection Fraction. Journal of Clinical Medicine, 15(3), 1172. https://doi.org/10.3390/jcm15031172

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