Order Article Reprints
Journal: J. Clin. Med., 2026
Volume: 15
Number: 4026
Article:
Comparable Fusion Response, but Increased Inflammatory Response, with Escherichia coli-Derived Recombinant Human Bone Morphogenetic Protein-2 in Posterior Lumbar Interbody Fusion Surgery
Authors:
by
Mu Ha Lee, Hyun Jun Jang, Kyung Hyun Kim, Jeong-Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Jae Keun Oh and Bong Ju Moon
Link:
https://www.mdpi.com/2077-0383/15/11/4026
MDPI offers high quality article reprints with convenient shipping to destinations worldwide. Each reprint features a 270 gsm bright white cover
and 105 gsm premium white paper, bound with two stitches for durability and printed in full color. The cover design is customized to your article
and designed to be complimentary to the journal.
![](mailto:?&subject=From%20MDPI%3A%20%22Comparable%20Fusion%20Response%2C%20but%20Increased%20Inflammatory%20Response%2C%20with%20Escherichia%20coli-Derived%20Recombinant%20Human%20Bone%20Morphogenetic%20Protein-2%20in%20Posterior%20Lumbar%20Interbody%20Fusion%20Surgery"&body=https://www.mdpi.com/3898912%3A%0A%0AComparable%20Fusion%20Response%2C%20but%20Increased%20Inflammatory%20Response%2C%20with%20Escherichia%20coli-Derived%20Recombinant%20Human%20Bone%20Morphogenetic%20Protein-2%20in%20Posterior%20Lumbar%20Interbody%20Fusion%20Surgery
Background%2FObjectives%3A%20This%20retrospective%20study%20aimed%20to%20evaluate%20the%20radiologic%20outcomes%20and%20changes%20in%20biochemical%20inflammatory%20markers%20following%20posterior%20lumbar%20interbody%20fusion%20%28PLIF%29%20with%20Escherichia%20coli-derived%20recombinant%20human%20bone%20morphogenetic%20protein-2%20%28E.BMP-2%29%2C%20compared%20with%20conventional%20autologous%20bone%20grafting.%20Methods%3A%20The%20study%20included%20112%20patients%20undergoing%20single-%20or%20two-level%20PLIF%20for%20degenerative%20lumbar%20disease%20between%202022%20and%202023%2C%20divided%20into%20E.BMP-2%20%28n%20%3D%2050%29%20and%20Control%20%28n%20%3D%2062%29%20groups.%20Radiological%20outcomes%2C%20including%20Bridwell%20grading%20system%20and%20adjacent%20vertebral%20body%20%28VB%29%20changes%2C%20and%20changes%20in%20biochemical%20inflammatory%20markers%E2%80%94white%20blood%20cell%20%28WBC%29%20count%2C%20C-reactive%20protein%20%28CRP%29%2C%20erythrocyte%20sedimentation%20rate%20%28ESR%29%2C%20and%20neutrophil%20count%E2%80%94were%20assessed.%20Clinical%20outcomes%20were%20also%20evaluated.%20Multivariate%20regression%20and%20propensity-score-matched%20analyses%2C%20and%20linear%20mixed-effects%20models%20were%20applied.%20Results%3A%20Fusion%20rates%20were%20comparable%20between%20the%20groups%20%2890.8%25%20vs.%2096.7%25%3B%20p%20%3D%200.466%29%3B%20adjusted[...]){kind=link}