FOOPAS Study: Functional Assessment and Prognostic Value in Aortic Valve Replacement for Patients ≥ 75 Years

Eckner, Dennis; Wicklein, Susanne; Gosch, Markus; Fischlein, Theodor; Habboub, Basel; Jessl, Jürgen; Pauschinger, Matthias; Vogt, Ferdinand

doi:10.3390/jcm15103750

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FOOPAS Study: Functional Assessment and Prognostic Value in Aortic Valve Replacement for Patients ≥ 75 Years

by

Dennis Eckner

^1,†

,

Susanne Wicklein

^2,†,

Markus Gosch

²,

Theodor Fischlein

³,

Basel Habboub

²,

Jürgen Jessl

¹,

Matthias Pauschinger

¹ and

Ferdinand Vogt

^3,*

¹

Department of Cardiology, Klinikum Nürnberg Paracelsus Medical University Nuremberg, 90471 Nuremberg, Germany

²

Department of Geriatric Medicine, Paracelsus Medical University Nuremberg, 90419 Nuremberg, Germany

³

Department of Cardiac Surgery, Paracelsus Medical University Nuremberg, 90419 Nurnberg, Germany

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

J. Clin. Med. 2026, 15(10), 3750; https://doi.org/10.3390/jcm15103750

Submission received: 19 April 2026 / Revised: 11 May 2026 / Accepted: 12 May 2026 / Published: 13 May 2026

(This article belongs to the Special Issue Aortic Valve Disease: Current Evolution and Future Opportunities)

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Abstract

Background: Because of demographic changes, the number of older patients undergoing cardiac interventions has increased. The most common indication in this group is aortic valve stenosis, treated with either surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVR), with good outcomes. Our study investigated whether the heart team’s choice of intervention (TAVI, SAVR, or conservative) is influenced by geriatric assessment results. Methods: This study was a single-centre, prospective, longitudinal case–control study conducted over 12 months and did not affect routine diagnostic examinations or clinical decisions. After risk stratification and clinical evaluation, patients were assigned to undergo TAVI, SAVR, or conservative management. Cardiological evaluation and geriatric assessment were performed for up to 12 months. Results: Of 135 patients (mean age 81 ± 4.6 years), 60% underwent TAVI, 29% SAVR, and 11% conservative therapy. Age, Frailty Score, cognition, and nutritional status were significantly associated with the heart team’s decision, whereas EuroSCORE II remained the only independent predictor of one-year mortality (OR 1.58, 95% CI 1.13–2.19, p = 0.007). One-year mortality was 9.9% (n = 11). Compared to the literature, one-year mortality was lower than expected, particularly in the intervention group. Conclusions: Single assessment tools did not have the power to predict mortality. Similar to other trials, a combination of different scores can assess the risk of mortality.

Keywords: aortic stenosis (AS); surgical aortic valve replacement (SAVR); transcatheter aortic valve replacement (TAVR); geriatric assessment; risk stratification

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MDPI and ACS Style

Eckner, D.; Wicklein, S.; Gosch, M.; Fischlein, T.; Habboub, B.; Jessl, J.; Pauschinger, M.; Vogt, F. FOOPAS Study: Functional Assessment and Prognostic Value in Aortic Valve Replacement for Patients ≥ 75 Years. J. Clin. Med. 2026, 15, 3750. https://doi.org/10.3390/jcm15103750

AMA Style

Eckner D, Wicklein S, Gosch M, Fischlein T, Habboub B, Jessl J, Pauschinger M, Vogt F. FOOPAS Study: Functional Assessment and Prognostic Value in Aortic Valve Replacement for Patients ≥ 75 Years. Journal of Clinical Medicine. 2026; 15(10):3750. https://doi.org/10.3390/jcm15103750

Chicago/Turabian Style

Eckner, Dennis, Susanne Wicklein, Markus Gosch, Theodor Fischlein, Basel Habboub, Jürgen Jessl, Matthias Pauschinger, and Ferdinand Vogt. 2026. "FOOPAS Study: Functional Assessment and Prognostic Value in Aortic Valve Replacement for Patients ≥ 75 Years" Journal of Clinical Medicine 15, no. 10: 3750. https://doi.org/10.3390/jcm15103750

APA Style

Eckner, D., Wicklein, S., Gosch, M., Fischlein, T., Habboub, B., Jessl, J., Pauschinger, M., & Vogt, F. (2026). FOOPAS Study: Functional Assessment and Prognostic Value in Aortic Valve Replacement for Patients ≥ 75 Years. Journal of Clinical Medicine, 15(10), 3750. https://doi.org/10.3390/jcm15103750

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FOOPAS Study: Functional Assessment and Prognostic Value in Aortic Valve Replacement for Patients ≥ 75 Years

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