Clinical Outcomes of Transradial Versus Transfemoral Approach in Rotational Atherectomy: Results from the Rotational Atherectomy in Calcified Lesions in Korea (ROCK) Registry
Abstract
:1. Introduction
2. Methods
2.1. Study Design and Population
2.2. RA Procedure
2.3. Clinical Outcomes and Definition
2.4. Statistical Analysis
3. Results
3.1. Baseline Characteristics
3.2. In-Hospital Events and Procedural Outcomes
3.3. Clinical Outcomes
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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TR Approach (n = 248) | TF Approach (n = 292) | p-Value | |
---|---|---|---|
Age, years | 72.5 ± 9.4 | 70.5 ± 10.6 | 0.024 |
Sex | 0.069 | ||
Male | 138 (55.7) | 185 (63.4) | |
Female | 110 (44.3) | 107 (36.6) | |
BMI | 24.6 ± 3.8 | 24.0 ± 4.0 | 0.073 |
Smoking | 39 (15.7) | 64 (21.9) | 0.068 |
HTN | 184 (74.2) | 231 (79.1) | 0.177 |
DM | 132 (53.2) | 173 (59.3)) | 0.160 |
Dyslipidemia | 110 (44.4) | 125 (42.8) | 0.718 |
Family history of CAD | 5 (2.0) | 6 (2.1) | 0.975 |
CKD | 28 (11.3) | 68 (23.3) | <0.001 |
Dialysis | 4 (1.6) | 45 (15.4) | <0.001 |
Previous PCI | 54 (21.8) | 85 (29.1) | 0.052 |
Previous CABG | 4 (1.6) | 20 (6.9) | 0.003 |
Previous MI | 24 (9.7) | 42 (14.4)) | 0.096 |
CVA | 36 (14.5) | 39 (13.4) | 0.698 |
PVD | 10 (4.0) | 29 (9.9) | 0.008 |
Heart failure | 22(8.9) | 55(18.8) | 0.001 |
Atrial fibrillation | 25 (10.1) | 24 (8.2) | 0.453 |
Clinical diagnosis | 0.558 | ||
Stable angina | 80 (32.3) | 94 (32.2) | |
Unstable angina | 87 (35.1) | 88 (30.1) | |
NSTEMI | 60 (24.2) | 74 (25.3) | |
STEMI | 6 (2.4) | 13 (4.5) | |
Silent ischemia | 15 (6.1) | 22 (7.5) | |
Triglyceride | 120.4 ± 69.8 | 119.0 ± 77.7 | 0.838 |
Total cholesterol | 147.2 ± 35.9 | 140.4 ± 40.8 | 0.047 |
LDL cholesterol | 88.6 ± 44.6 | 81.3 ± 34.1 | 0.048 |
HDL cholesterol | 46.7 ± 14.7 | 45.5 ± 14.4 | 0.350 |
hsCRP | 2.0 ± 4.8 | 3.9 ± 12.5 | 0.107 |
HbA1c | 6.8 ± 1.4 | 6.6 ± 1.4 | 0.240 |
Hemoglobin | 12.6 ± 2.9 | 12.1 ± 1.9 | 0.014 |
Platelet count | 225.3 ± 67.8 | 214.0 ± 73.3 | 0.065 |
Drug | |||
DOAC | 12 (4.8) | 4 (1.4) | 0.018 |
DAPT | 241 (97.2) | 278 (95.2) | 0.238 |
Aspirin | 241 (97.2) | 288 (98.6) | 0.234 |
P2Y12 inhibitor | 244 (98.4) | 286 (98.0) | 0.760 |
Statin | 231 (93.2) | 271(92.8) | 0.879 |
TR Approach (n = 248) | TF Approach (n = 292) | p-Value | |
---|---|---|---|
Lesion classification | 0.823 | ||
A, n (%) | 1 (0.4) | 2 (0.7) | |
B1, n (%) | 20 (8.1) | 20 (6.9) | |
B2, n (%) | 26 (10.5) | 26 (8.9) | |
C, n (%) | 201 (81.1) | 244(83.6) | |
Vessel diseases | 0.815 | ||
1VD, n (%) | 56 (22.6) | 60 (20.6) | |
2VD, n (%) | 76 (30.7) | 95 (32.5) | |
3VD, n (%) | 116 (46.8) | 137 (46.9) | |
MVD, n (%) | 192 (77.4) | 232 (79.5) | 0.567 |
LM disease | 31 (12.5) | 43 (14.7) | 0.454 |
pre EF | 55.5 ± 12.2 | 50.9 ± 14.0 | <0.001 |
Use of IVUS | 120 (48.4) | 129 (44.2) | 0.328 |
Mean stent diameter, mm | 3.0 ± 0.4 | 3.0 ± 0.4 | 0.270 |
Total number of stent, mm | 2.2 ± 1.1 | 2.5 ± 1.2 | 0.001 |
Total stent length, mm | 61.8 ± 32.4 | 70.7 ± 35.2 | 0.004 |
Max burr size, mm | 1.50 ± 0.20 | 1.50 ± 0.20 | 0.367 |
Procedure time, min | 72.4 ± 38.1 | 85.1 ± 58.7 | 0.004 |
Procedure success, n (%) | 242 (97.6) | 278 (95.2) | 0.145 |
TR Approach (n = 248) | TF Approach (n = 292) | p-Value | |
---|---|---|---|
In-hospital events | |||
In-hospital MACCE, n (%) | 28 (11.3) | 32 (11.0) | 0.903 |
In-hospital death, n (%) | 5 (2.0) | 6 (2.1) | 0.975 |
Urgent CABG/PCI, n (%) | 2 (0.8) | 7 (2.4) | 0.189 |
Peri-procedural MI, n (%) | 21 (8.5) | 24 (8.2) | 0.917 |
In-hospital CVA, n (%) | 1 (0.4) | 1 (0.3) | >0.999 |
Procedural outcomes | |||
Coronary dissection, n (%) | 20 (8.0) | 26 (9.0) | 0.680 |
Temporary pacemaker during procedure, n (%) | 2 (0.8) | 14 (4.8) | 0.007 |
Coronary perforation, n (%) | 4 (1.6) | 6 (2.1) | 0.760 |
In-hospital bleeding, n (%) | 8 (3.2) | 19 (6.5) | 0.081 |
TR Approach (n = 248) | TF Approach (n = 292) | p-Value | Univariate HR (95% CI) | p-Value | Multivariate HR ** (95% CI) | p-Value | |
---|---|---|---|---|---|---|---|
MACCE | 28 (11.3) | 52 (17.8) | 0.034 | 1.643 (1.038–2.601) | 0.034 | 1.520 (0.889–2.600) | 0.126 |
All cause of death | 20 (8.1) | 26 (8.9) | 0.728 | 1.124 (0.627–2.013) | 0.695 | 1.230 (0.610–2.482) | 0.562 |
Cardiac death | 10 (4.0) | 20 (6.9) | 0.154 | 1.732 (0.811–3.700) | 0.156 | 1.699 (0.686–4.205) | 0.252 |
MI | 7 (2.8) | 13 (4.5) | 0.318 | 1.639 (0.654–4.108) | 0.292 | 1.601 (0.536–4.786) | 0.400 |
RR | 21 (8.5) | 33 (11.3) | 0.274 | 1.399 (0.809–2.417) | 0.230 | 1.140 (0.615–2.114) | 0.676 |
TVR | 16 (6.5) | 29 (9.9) | 0.145 | 1.622 (0.881–2.986) | 0.121 | 1.212 (0.606–2.424) | 0.587 |
TLR | 13 (5.2) | 25 (8.6) | 0.133 | 1.706 (0.873–3.334) | 0.118 | 1.245 (0.582–2.663) | 0.572 |
CVA | 4 (1.6) | 6 (2.1) | 0.760 | 1.301 (0.367–4.610) | 0.684 | 1.479 (0.230–9.512) | 0.681 |
ST | 2 (0.8) | 5 (1.7) | 0.461 | 2.163 (0.420–11.151) | 0.356 | 2.224 (0.343–14.414) | 0.402 |
Total bleeding | 13 (5.2) | 19 (6.5) | 0.535 | 1.280 (0.632–2.592) | 0.493 | 1.214 (0.526–2.802) | 0.649 |
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Kim, K.; Jung, J.; Her, S.-H.; Lee, K.; Jung, J.-H.; Yoo, K.-D.; Moon, K.-W.; Moon, D.; Lee, S.-N.; Jang, W.-Y.; et al. Clinical Outcomes of Transradial Versus Transfemoral Approach in Rotational Atherectomy: Results from the Rotational Atherectomy in Calcified Lesions in Korea (ROCK) Registry. J. Clin. Med. 2025, 14, 3066. https://doi.org/10.3390/jcm14093066
Kim K, Jung J, Her S-H, Lee K, Jung J-H, Yoo K-D, Moon K-W, Moon D, Lee S-N, Jang W-Y, et al. Clinical Outcomes of Transradial Versus Transfemoral Approach in Rotational Atherectomy: Results from the Rotational Atherectomy in Calcified Lesions in Korea (ROCK) Registry. Journal of Clinical Medicine. 2025; 14(9):3066. https://doi.org/10.3390/jcm14093066
Chicago/Turabian StyleKim, Kyunyeon, Jin Jung, Sung-Ho Her, Kyusup Lee, Ji-Hoon Jung, Ki-Dong Yoo, Keon-Woong Moon, Donggyu Moon, Su-Nam Lee, Won-Young Jang, and et al. 2025. "Clinical Outcomes of Transradial Versus Transfemoral Approach in Rotational Atherectomy: Results from the Rotational Atherectomy in Calcified Lesions in Korea (ROCK) Registry" Journal of Clinical Medicine 14, no. 9: 3066. https://doi.org/10.3390/jcm14093066
APA StyleKim, K., Jung, J., Her, S.-H., Lee, K., Jung, J.-H., Yoo, K.-D., Moon, K.-W., Moon, D., Lee, S.-N., Jang, W.-Y., Choi, I.-J., Lee, J.-H., Lee, J.-H., Lee, S.-R., Lee, S.-W., Yun, K.-H., & Lee, H.-J. (2025). Clinical Outcomes of Transradial Versus Transfemoral Approach in Rotational Atherectomy: Results from the Rotational Atherectomy in Calcified Lesions in Korea (ROCK) Registry. Journal of Clinical Medicine, 14(9), 3066. https://doi.org/10.3390/jcm14093066