Otolaryngological Problems Among Patients with Growth Hormone Deficiency—A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Searching and Data Screening
2.3. Eligibility Criteria
2.4. Data Extraction and Processing
3. Results
3.1. Databases Search Results
3.2. Included Studies Characteristics
3.3. Risk of Bias Assessment
3.4. Results of Data Synthesis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
AGHD | Acquired growth hormone deficiency |
GH | Growth hormone |
GHD | Growth hormone deficiency |
GHRHR | GH-releasing hormone receptor |
HFA | High frequency averages |
IGF-1 | Insulin-like growth factor 1 |
JAK2 | Janus kinase 2 protein |
OME | Otitis media with effusion |
ENT | Otorhinolaryngological |
PTA | Pure-tone averages |
SOVTT | Semi-occluded vocal tract therapy |
TEOAEs | Transient evoked otoacoustic emissions |
V-RQOL | Voice-Related Quality-of-Life |
References
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Inclusion Criteria | Exclusion Criteria |
---|---|
Patients with the diagnosis of GHD who underwent ENT examination at any time | Patients with short stature due to genetic conditions, e.g., Turner syndrome, Prader–Willi syndrome |
Case report/case series |
First Author Name | Number of Patients with Growth Hormone Deficiency | Number of Patients with Otorhinolaryngological Symptoms | Symptoms Experienced by Patients | Newcastle–Ottawa Scale (n) |
---|---|---|---|---|
Moore et al. [5] | 8 | 5 | High-pitched voice | 7 |
Valença et al. [6] | 33 | 33 | High-pitched voice | 7 |
Valença et al. [7] * | 33 | 33 | High-pitched voice | 7 |
Prado-Barreto et al. [8] | 26 | 26 | Hearing loss, dizziness, misophonia | 7 |
Baretto et al. [9] | 23 | 23 | Laryngopharyngeal reflux, vocal abnormalities | 7 |
de Andreade et al. [10] * | 17 | 17 | High-pitched voice | 7 |
de Andreade et al. [11] * | 17 | 17 | High-pitched voice | 7 |
Santos-Carvalho et al. [12] | 15 | 10 | Vestibular impairment | 8 |
Kocyigit et al. [13] | 46 | 7 | Hearing loss, tinnitus, vertigo | 8 |
Kocyigit et al. [14] | 179 | 54 | Otitis media with effusion | 8 |
Muus et al. [15] | 209 | 173 | Hearing loss | 8 |
Otorhinolaryngological Symptoms | N (%) |
---|---|
Yes | 331 (61.4) |
No | 208 (38.6) |
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Share and Cite
Abdulaziz-Opiela, G.; Witkowski, P.; Późniak, Y.; Bajdor, J.; Bautembach, J.; Myśliwiec, M.; Mikaszewski, B. Otolaryngological Problems Among Patients with Growth Hormone Deficiency—A Systematic Review. J. Clin. Med. 2025, 14, 3064. https://doi.org/10.3390/jcm14093064
Abdulaziz-Opiela G, Witkowski P, Późniak Y, Bajdor J, Bautembach J, Myśliwiec M, Mikaszewski B. Otolaryngological Problems Among Patients with Growth Hormone Deficiency—A Systematic Review. Journal of Clinical Medicine. 2025; 14(9):3064. https://doi.org/10.3390/jcm14093064
Chicago/Turabian StyleAbdulaziz-Opiela, Gazala, Paweł Witkowski, Yasmina Późniak, Julia Bajdor, Joanna Bautembach, Małgorzata Myśliwiec, and Bogusław Mikaszewski. 2025. "Otolaryngological Problems Among Patients with Growth Hormone Deficiency—A Systematic Review" Journal of Clinical Medicine 14, no. 9: 3064. https://doi.org/10.3390/jcm14093064
APA StyleAbdulaziz-Opiela, G., Witkowski, P., Późniak, Y., Bajdor, J., Bautembach, J., Myśliwiec, M., & Mikaszewski, B. (2025). Otolaryngological Problems Among Patients with Growth Hormone Deficiency—A Systematic Review. Journal of Clinical Medicine, 14(9), 3064. https://doi.org/10.3390/jcm14093064