Wearable Technology in Gastroenterology: Current Applications and Future Directions
Abstract
:1. Introduction
2. Wearable Technology for Inflammatory Bowel Disease (IBD)
3. Wearable Technology for Motility Disorders
4. Wearable Technology for Cirrhosis
5. Remote Patient Monitoring (RPM) Using Smartphone Apps
6. Challenges
7. Conclusions and Future Directions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
PPG | Photoplethysmography |
HR | Heart rate |
ECG | Electrocardiography |
CGM | Continuous glucose monitoring |
FDA | Food and Drug Administration |
IBD | Inflammatory Bowel Disease |
ANS | Autonomic Nervous System |
HRV | Heart Rate Variability |
UC | Ulcerative colitis |
CRP | C-reactive protein |
IL-1b | interleukin-1beta |
TNF-a | tumor necrosis factor-alpha |
GI | gastrointestinal |
EGG | electrogastrogram |
EMR | electronic medical record |
HIPAA | Health Insurance Portability and Accountability Act |
PHI | Patient Health Information |
HITECH | Health Information Technology for Economic and Clinical Health Act |
RCT | Randomized Controlled Trial |
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Device | Clinical Application | Patient Outcomes | Study Conclusions |
---|---|---|---|
VitalPatch (Hirten et al. [2]) | HRV monitoring and UC flares | Measured HRV of patients with UC every 4 weeks for 72 continuous hours for the study duration of 9 months. HRV was analyzed by low frequency (LF) bands, high frequency (HF) bands, and LF to HF power (LFHF). | HRV reduction inversely correlated with inflammatory flare detected by FC (p < 0.001 for all 3 frequencies), and CRP (p < 0.001 for HF and LF; p = 0.09 for LFHF). HRV reduction significantly correlated with symptomatic flare detected by Simple Clinical Colitis Activity Index using only LFHF (p = 0.03). |
WHOOP (DiJoseph et al. [3]) | HRV monitoring and UC flares | Feasibility study in which patient used WHOOP to record symptoms. HRV was correlated to IBD related symptoms and monthly collections of SCCAI. | Two of the enrolled patients communicated concern for disease flare based on HRV and RHR changes detected by WHOOP which correlated with flare by serologic testing. |
SWEATSENSER (Jaganath et al. [4]) | Detect IBD biomarkers in sweat | Used a novel device to assess levels of IL-6, IL-8, IL-10, and TNF-a in sweat when compared with standard serologic testing | SWEATSENSER demonstrated a correlation of Pearson’s r > 0.98 for the study biomarkers when compared with the standard method. |
IBD AWARE (Hirten et al. [6]) | Detect IBD biomarkers in sweat | Used a novel device to assess sweat levels of CRP and IL-6 continuously compared to daily checks of serum CRP and IL-6 in hospitalized patients | Correlation between CRP measured in serum (lab-based) and sweat (from the IBD AWARE device) for the full data set of CRP values: R2 = 0.5278, serum CRP values of ≤20 μg/mL: R2 = 0.7108, serum CRP values of ≤10 μg/mL: R2 = 0.883. Correlation between IL-6 measured in serum (lab-based) and sweat (from the IBD AWARE device) for the full data set of IL-6 values: R2 = 0.601, serum IL-6 values of ≤20 pg/mL: R2 = 0.5732, serum IL-6 values of ≤10 pg/mL: R2 = 0.7231. |
Novel EGG sensor (Gharibans et al. [8]) | Mapping gastric electric activity | Tested a novel gastric mapping device tested in a cohort of 24 healthy subjects to define reliability and characterize features of normal gastric activity (30 m fasting, standardized meal, and 4 h postprandial). | Mean amplitude significantly increased during the 0–2 h postprandial period (p < 0.001 vs. fasted period) and during the 2–4 h postprandial period (p = 0.0001) |
Novel EGG sensor (Vujic et al. [9]) | Mapping gastric electric activity | Developed a novel scuba knit belt with a hydrogel electrode montage. Patients wore the belt in a free living environment during the recording. | The hydrogel electrode array captured gastric activity as well as artifact electrocardiogram activity. |
Bluetooth scale and remote weight tracking (Bloom et al. [11]) | Reduce cirrhosis admissions | Telemonitoring system that tracks patients’ weight remotely through Bluetooth-enabled scales and provides automated, early alerts to providers about weight changes. The outcomes included global costs, number of hospital admissions, office visits, and paracenteses. | Standard of care led to nine more admissions in a 6-month period than a telemonitoring intervention, while telemonitoring led to 28 additional outpatient LVPs in the same period. Cost of standard of care for 100 patients with cirrhotic ascites over a 6-month period is $1,221,500 and cost of care with a telemonitoring intervention was $167,500 less expensive. |
Isansys Lifetouch or Holter monitor (Jansen et al. [13]) | HRV and cirrhosis decompensations | Continuous HRV assessment in patients with cirrhosis in the outpatient setting, with acute decompensations, and with acute on chronic liver failure. | All cirrhosis patients had lower HRV compared to healthy subjects. Patients with acute decompensations had lower HRV compared to cirrhosis outpatients (p < 0.001), without significant differences in mean arterial pressure. Patients with acute on chronic liver failure had even lower HRV (p = 0.02). |
App | Clinical Application | Patient Outcomes | Study Conclusions |
---|---|---|---|
myIBDcoach (George and Cross [14]) | IBD monitoring | RCT which compared telemedicine to standard of care. Patients were followed for one year after randomization. | Mean number of outpatient visits and telephone encounters were decreased in the telemedicine group (p < 0.0001 and p = 0.0003, respectively). Less patients were hospitalized in the telemedicine group (p = 0.046). |
Mynexuzhealth (Coenen et al. [15]) | IBD monitoring | Patients completed questionnaires on an app created by the study creators, and the data were sent to directly to the electronic medical record (EMR). | Nine patients triggered alerts for disease activity. For 8 of those patients, symptoms resolved spontaneously. One patient underwent endoscopy which confirmed IBD flare and treatment was changed. |
IBDsmart and IBDoc (McCombie et al. [16]) | IBD monitoring and FC detection | Patients used two apps created by the study creators (IBDsmart and IBDoc) to compare outpatient management vs. standard care. | Outpatient appointment numbers were reduced in smartphone app care (p < 0.001) |
healthPROMISE (Zhen et al. [17]) | IBD monitoring | Using the healthPROMISE app created by the study’s creators, metrics such as patient satisfaction, quality of life, and symptoms were collected and sent to the EMR. | The number of ER visits and hospitalizations compared to the prior year (without use of the app) significantly decreased from 25% of patients (8/32) to 3% (1/32) (p = 0.03). |
MyHealthyGut (Dowd et al. [18]) | Celiac disease management | Assess the effectiveness the app (MyHealthyGut) to help patients with celiac disease manage their disease and improve gut health. | Only participants the group given delayed access to use the app for a one-month period reported significant improvements in adherence to a gluten free (p < 0.001). |
EncephalApp (Louissaint et al. [19]) | Cirrhosis management | Assess patient acceptance of apps for management of cirrhosis using EncephalApp. | Intention of the patients to use the application was associated with perceived usefulness (β: 0.4, 95% CI: 0.3–0.5) and the presence of a caregiver (β: 1.1, 95% CI: 0.2–2.0). 71% agreed to download the app but actual usage was 32%. |
HBI app (Echarri et al. [20]) | Crohns Disease monitoring | Evaluate if a patient administered HBI on an app agrees with physician administered HBI in clinic. | All assessments showed a high percentage of agreement. Positive predictive value (PPV) for remission was 98.2%, and negative predictive value was 76.7%. |
IBD app (Chugh et al. [21]) | IBD monitoring | Evaluate the use of an app to improve IBD care and patient satisfaction and engagement. App data were directly sent to the EMR. | Patient satisfaction was moderately high with a median score of 8. Continuous engagement was significantly increased if patients reported presence of extraintestinal symptoms (7%, 95% CI: 0.01–0.14; p = 0.04). |
eIBD (Zand et al. [22]) | IBD monitoring | A feasibility study to assess patient satisfaction for IBD care using an IBD care app by patients and providers. | 68% of patients were satisfied with communication using the app. 54% of patients reported improved perception of disease control and quality of life. |
CirrhoCare (Kazankov et al. [23]) | Cirrhosis monitoring | Feasibility to assess the management of acute decompensations of cirrhosis remotely using the CirrhoCare app. | Fifteen patients showed good engagement (≥4 readings/week), 2 moderate (2–3/week), and 3 poor (<2/week). Five patients had 8 readmissions for a median of 5 days, and none required hospitalization for >14 days. Outcomes require further validation in an RCT. |
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Reddy, K.D.; Chawla, S. Wearable Technology in Gastroenterology: Current Applications and Future Directions. J. Clin. Med. 2025, 14, 2403. https://doi.org/10.3390/jcm14072403
Reddy KD, Chawla S. Wearable Technology in Gastroenterology: Current Applications and Future Directions. Journal of Clinical Medicine. 2025; 14(7):2403. https://doi.org/10.3390/jcm14072403
Chicago/Turabian StyleReddy, Keerthi D., and Saurabh Chawla. 2025. "Wearable Technology in Gastroenterology: Current Applications and Future Directions" Journal of Clinical Medicine 14, no. 7: 2403. https://doi.org/10.3390/jcm14072403
APA StyleReddy, K. D., & Chawla, S. (2025). Wearable Technology in Gastroenterology: Current Applications and Future Directions. Journal of Clinical Medicine, 14(7), 2403. https://doi.org/10.3390/jcm14072403