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Volume 14
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10.3390/jcm14051406
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Article

Evaluation of Platelet Indices and Inflammation Markers in Preeclampsia

by
Betül Tokgöz Çakır
1,*,
Gizem Aktemur
1,
Gülşan Karabay
1,
Zeynep Şeyhanlı
1,
Sevinç Çetin
2,
Ahmet Arif Filiz
1,
Nazan Vanlı Tonyalı
1 and
Ali Turhan Çağlar
1
1
Department of Perinatology, Ankara Etlik City Hospital, Ankara 06170, Türkiye
2
Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, Ankara 06170, Türkiye
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(5), 1406; https://doi.org/10.3390/jcm14051406
Submission received: 16 January 2025 / Revised: 4 February 2025 / Accepted: 10 February 2025 / Published: 20 February 2025
(This article belongs to the Section Obstetrics & Gynecology)
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Abstract

Background: Preeclampsia is a serious pregnancy complication known to be related to the pathophysiology of platelet dysfunction and inflammation. The aim of this study was to investigate the role of platelet indices and inflammatory markers in preeclampsia and their importance in predicting adverse neonatal outcomes. Methods: A total of 118 preeclampsia cases (84 with mild preeclampsia and 34 with severe preeclampsia) and 118 healthy pregnant women were included in the study. Blood samples obtained at the time of preeclampsia diagnosis were analyzed for platelet indices (platelet count (PC), platelet distribution width (PDW), mean platelet volume (MPV), and platelet/large cell ratio (P-LCR)) and inflammation indices (neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume-to-lymphocyte ratio (MPVLR)). Results: The PC and PLR were lower in the severe preeclampsia group compared to the other groups. The PDW was higher in both mild and severe preeclampsia groups compared to the control group. A PDW value above 13.15 was identified as a significant predictor of composite adverse neonatal outcomes (area under the curve (AUC): 0.633; sensitivity: 60.9%; specificity: 58%). Conclusions: PC and PLR decrease in severe preeclampsia. This study highlights the potential of PDW as a marker for predicting adverse neonatal outcomes in preeclampsia.
Keywords: inflammation markers; platelet indices; platelet distribution width (PDW) inflammation markers; platelet indices; platelet distribution width (PDW)

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MDPI and ACS Style

Tokgöz Çakır, B.; Aktemur, G.; Karabay, G.; Şeyhanlı, Z.; Çetin, S.; Filiz, A.A.; Vanlı Tonyalı, N.; Çağlar, A.T. Evaluation of Platelet Indices and Inflammation Markers in Preeclampsia. J. Clin. Med. 2025, 14, 1406. https://doi.org/10.3390/jcm14051406

AMA Style

Tokgöz Çakır B, Aktemur G, Karabay G, Şeyhanlı Z, Çetin S, Filiz AA, Vanlı Tonyalı N, Çağlar AT. Evaluation of Platelet Indices and Inflammation Markers in Preeclampsia. Journal of Clinical Medicine. 2025; 14(5):1406. https://doi.org/10.3390/jcm14051406

Chicago/Turabian Style

Tokgöz Çakır, Betül, Gizem Aktemur, Gülşan Karabay, Zeynep Şeyhanlı, Sevinç Çetin, Ahmet Arif Filiz, Nazan Vanlı Tonyalı, and Ali Turhan Çağlar. 2025. "Evaluation of Platelet Indices and Inflammation Markers in Preeclampsia" Journal of Clinical Medicine 14, no. 5: 1406. https://doi.org/10.3390/jcm14051406

APA Style

Tokgöz Çakır, B., Aktemur, G., Karabay, G., Şeyhanlı, Z., Çetin, S., Filiz, A. A., Vanlı Tonyalı, N., & Çağlar, A. T. (2025). Evaluation of Platelet Indices and Inflammation Markers in Preeclampsia. Journal of Clinical Medicine, 14(5), 1406. https://doi.org/10.3390/jcm14051406

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