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Review

Early Autonomic Dysfunction in Traumatic Brain Injury: An Article Review on the Impact on Multiple Organ Dysfunction

by
Pattrapun Wongsripuemtet
1,2,*,
Tetsu Ohnuma
1,3,
Zeljka Minic
4,5,
Monica S. Vavilala
6,
Joseph B. Miller
7,
Daniel T. Laskowitz
8,
William J. Meurer
9,10,
Xiao Hu
11,
Frederick K. Korley
9,12,
Huaxin Sheng
3 and
Vijay Krishnamoorthy
1,3
1
Critical Care and Perioperative Population Health Research (CAPER) Program, Department of Anesthesiology, Duke University, Durham, NC 27708, USA
2
Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
3
Departments of Anesthesiology, Duke University, Durham, NC 27708, USA
4
Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI 48202, USA
5
Faculty of Biotechnology and Drug Development, University of Rijeka, 51000 Rijeka, Croatia
6
Departments of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA
7
Department of Emergency Medicine, Henry Ford Health System, Detroit, MI 48202, USA
8
Department of Neurology, Duke University, Durham, NC 27708, USA
9
Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109, USA
10
Department of Emergency Neurology, University of Michigan, Ann Arbor, MI 48109, USA
11
School of Nursing, Emory University, Atlanta, GA 30322, USA
12
The Max Harry Weil Institute for Critical Care Research and Innovation, Ann Arbor, MI 48109, USA
 
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*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(2), 557; https://doi.org/10.3390/jcm14020557
Submission received: 30 November 2024 / Revised: 9 January 2025 / Accepted: 14 January 2025 / Published: 16 January 2025
(This article belongs to the Special Issue Traumatic Brain Injury (TBI): Clinical Updates and Perspectives)
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Abstract

Background/Objectives: Traumatic brain injury (TBI) is a complex condition and a leading cause of injury-related disability and death, with significant impacts on patient outcomes. Extracranial organ involvement plays a critical role in the outcome of patients following TBI. Method: This review aims to provide a comprehensive overview of the pathophysiology, clinical presentation, and challenges in diagnosing patients with autonomic dysfunction after TBI. The databases used in this review include PubMed/MEDLINE, Cochrane Central Register, and Scopus. Results: Of 172 articles identified for screening, 98 were ultimately included in the review. Conclusion: This review summarized the current evidence on the pathophysiology, clinical presentation, and diagnosis of early autonomic dysfunction. It also emphasizes the effects of autonomic dysfunction on end-organ damage. These insights aim to guide clinicians and researchers toward improving the care for and understanding of autonomic dysfunction in TBI patients, while underscoring the need for further research in this area.
Keywords: traumatic brain injury; autonomic dysfunction; multiorgan dysfunction traumatic brain injury; autonomic dysfunction; multiorgan dysfunction

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MDPI and ACS Style

Wongsripuemtet, P.; Ohnuma, T.; Minic, Z.; Vavilala, M.S.; Miller, J.B.; Laskowitz, D.T.; Meurer, W.J.; Hu, X.; Korley, F.K.; Sheng, H.; et al. Early Autonomic Dysfunction in Traumatic Brain Injury: An Article Review on the Impact on Multiple Organ Dysfunction. J. Clin. Med. 2025, 14, 557. https://doi.org/10.3390/jcm14020557

AMA Style

Wongsripuemtet P, Ohnuma T, Minic Z, Vavilala MS, Miller JB, Laskowitz DT, Meurer WJ, Hu X, Korley FK, Sheng H, et al. Early Autonomic Dysfunction in Traumatic Brain Injury: An Article Review on the Impact on Multiple Organ Dysfunction. Journal of Clinical Medicine. 2025; 14(2):557. https://doi.org/10.3390/jcm14020557

Chicago/Turabian Style

Wongsripuemtet, Pattrapun, Tetsu Ohnuma, Zeljka Minic, Monica S. Vavilala, Joseph B. Miller, Daniel T. Laskowitz, William J. Meurer, Xiao Hu, Frederick K. Korley, Huaxin Sheng, and et al. 2025. "Early Autonomic Dysfunction in Traumatic Brain Injury: An Article Review on the Impact on Multiple Organ Dysfunction" Journal of Clinical Medicine 14, no. 2: 557. https://doi.org/10.3390/jcm14020557

APA Style

Wongsripuemtet, P., Ohnuma, T., Minic, Z., Vavilala, M. S., Miller, J. B., Laskowitz, D. T., Meurer, W. J., Hu, X., Korley, F. K., Sheng, H., & Krishnamoorthy, V. (2025). Early Autonomic Dysfunction in Traumatic Brain Injury: An Article Review on the Impact on Multiple Organ Dysfunction. Journal of Clinical Medicine, 14(2), 557. https://doi.org/10.3390/jcm14020557

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