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Article

Effect of Leukocyte- and Platelet-Rich Fibrin on Peri-Implant Mucosal Thickness in Edentulous Patients Treated with Mandibular Implant-Retained Overdentures: A Randomized Controlled Trial

1
San Camilo Hospital, San Felipe, Chile
2
Faculty of Dentistry, Universidad de Chile, Santiago 8320000, Chile
3
Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich, 8006 Zurich, Switzerland
4
Universidad Autonoma de Chile, Health Science Faculty, Santiago 8940000, Chile
5
Department of Periodontology, Medical University of Vienna, 1090 Vienna, Austria
6
School of Dentistry, Universidad Andres Bello, Santiago 7591538, Chile
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(19), 6917; https://doi.org/10.3390/jcm14196917
Submission received: 1 September 2025 / Revised: 24 September 2025 / Accepted: 28 September 2025 / Published: 29 September 2025
(This article belongs to the Special Issue Advances in Periodontitis and Other Periodontal Diseases)

Abstract

Background/Objectives: The maintenance of peri-implant soft tissue health is critical for the long-term success of implant therapy, particularly in edentulous patients rehabilitated with mandibular overdentures. Leukocyte- and platelet-rich fibrin (L-PRF) has been proposed as an autologous biomaterial to enhance peri-implant tissue quality. This randomized controlled clinical trial evaluated the effect of L-PRF on peri-implant mucosal thickness in edentulous patients treated with mandibular implant-retained overdentures. Methods: Edentulous patients received two interforaminal implants to retain a mandibular overdenture and were randomly assigned to a test group (L-PRF applied during surgery) or a control group (standard protocol without L-PRF). Clinical measurements of keratinized mucosal thickness and width were recorded at baseline, 12 weeks, and 24 weeks. Volumetric analyses of soft and hard tissue changes were performed using digital superimposition of STL models. The trial was conducted in accordance with the Declaration of Helsinki and approved by the Scientific Ethics Committee of the Aconcagua Health Service. All participants provided written informed consent. Results: A significant increase in keratinized mucosal thickness was observed in the L-PRF group at 12 and 24 weeks compared with baseline (p < 0.01). No significant differences were detected between the groups in soft tissue volume (p = 0.12) or bone volume (p = 0.45). Mucosal width remained stable in both groups throughout follow-up. Conclusions: The application of L-PRF at implant placement resulted in a significant gain in peri-implant mucosal thickness, suggesting a soft tissue modulating effect. Enhancing keratinized mucosal thickness during implant surgery may improve peri-implant tissue quality and support long-term stability of mandibular overdentures.
Keywords: dental implants; guided tissue regeneration; jaw; edentulous; platelet-rich fibrin dental implants; guided tissue regeneration; jaw; edentulous; platelet-rich fibrin

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MDPI and ACS Style

Moreno, X.; Neira, P.; Strauss, F.J.; Mery, M.I.; Gruber, R.; Cavalla, F. Effect of Leukocyte- and Platelet-Rich Fibrin on Peri-Implant Mucosal Thickness in Edentulous Patients Treated with Mandibular Implant-Retained Overdentures: A Randomized Controlled Trial. J. Clin. Med. 2025, 14, 6917. https://doi.org/10.3390/jcm14196917

AMA Style

Moreno X, Neira P, Strauss FJ, Mery MI, Gruber R, Cavalla F. Effect of Leukocyte- and Platelet-Rich Fibrin on Peri-Implant Mucosal Thickness in Edentulous Patients Treated with Mandibular Implant-Retained Overdentures: A Randomized Controlled Trial. Journal of Clinical Medicine. 2025; 14(19):6917. https://doi.org/10.3390/jcm14196917

Chicago/Turabian Style

Moreno, Ximena, Patricio Neira, Franz J. Strauss, María Ignacia Mery, Reinhard Gruber, and Franco Cavalla. 2025. "Effect of Leukocyte- and Platelet-Rich Fibrin on Peri-Implant Mucosal Thickness in Edentulous Patients Treated with Mandibular Implant-Retained Overdentures: A Randomized Controlled Trial" Journal of Clinical Medicine 14, no. 19: 6917. https://doi.org/10.3390/jcm14196917

APA Style

Moreno, X., Neira, P., Strauss, F. J., Mery, M. I., Gruber, R., & Cavalla, F. (2025). Effect of Leukocyte- and Platelet-Rich Fibrin on Peri-Implant Mucosal Thickness in Edentulous Patients Treated with Mandibular Implant-Retained Overdentures: A Randomized Controlled Trial. Journal of Clinical Medicine, 14(19), 6917. https://doi.org/10.3390/jcm14196917

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