Impact of Transcatheter Edge-to-Edge Repair on Tricuspid Annular Remodeling in Patients with Tricuspid Regurgitation
Abstract
1. Introduction
2. Methods
2.1. Study Population
2.2. Echocardiographic Evaluation
2.3. Tricuspid Annulus Analysis
2.4. Statistical Analysis
3. Results
3.1. Clinical and Echocardiographic Characteristics
3.2. Operative Outcomes
3.3. Echocardiographic Outcomes
3.4. Acute Tricuspid Annulus Remodelling
4. Discussion
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
TR | Tricuspid Regurgitation |
TA | Tricuspid Annulus |
RV | Right Ventricle |
TV | Tricuspid Valve |
3D | Three Dimensional |
CMR | Cardiac Magnetic Resonance |
TEE | Transesophageal Echocardiogram |
AF | Atrial Fibrillation |
References
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Parameters | All Patients (n = 26) |
---|---|
Age (years) | 79.3 (64–88) |
Female Sex | 23 (88.5%) |
Body mass index (kg/m2) | 25.2 (16.7–32.9) |
Arterial Hypertension | 18 (69.2%) |
Diabetes | 2 (7.7%) |
Dyslipidemia | 14 (53.8%) |
Smoke | 1 (3.8%) |
NYHA Class | |
I | 0 (0%) |
II | 8 (30.8%) |
III | 17 (65.4%) |
IV | 1 (3.8%) |
Coronary Artery Disease | 8 (30.8%) |
PCI | 5 (19.2%) |
CABG | 1 (3.8%) |
Valvular Intervention | 8 (30.8%) |
Aortic Valve Replacement | 2 |
Mitral Valve Replacement | 4 |
Mitral Valve Repair | 2 |
Tricuspid Valve Repair | 1 |
Mitraclip | 1 |
Atrial Fibrillation | 24 (92.3%) |
PMK/ICD | 4 (15.4%) |
COPD | 3 (11.5%) |
HF Hospitalization | 8 (30.8%) |
Peripheral Edema | 11 (42.3%) |
Diuretics | 26 (100.0%) |
Hemoglobin (g/dL) | 12.51 ± 1.49 |
CKD (eGFR < 60 mL/min) | 15 (57.7%) |
Creatinine (mg/dL) | 1.08 ± 0.40 |
NTproBNP (pg/mL) | 3234 ± 2948 |
Parameters | All Patients (n = 26) |
---|---|
Sinus rhythm | 3 (11.5%) |
Atrial Fibrillation/Atrial Flutter | 22 (84.7%) |
Pacemaker rhythm | 1 (3.8%) |
EDA (cmq) | 21.15 ± 6.06 |
FAC (%) | 41.43 ± 5.69 |
TAPSE (mm) | 18.08 ± 2.07 |
PAPS (mmHg) | 49.65 ± 16.59 |
EF (%) | 58.67 ± 7.14 |
Tricuspid Regurgitation | |
Mild | 0 (0%) |
Moderate | 0 (0%) |
Severe | 12 (46.2%) |
Massive | 3 (11.5%) |
Torrential | 11 (42.3%) |
Primary Mechanism | |
Atrial Functional | 21 (80.8%) |
Ventricular Functional | 2 (7.7%) |
Primary | 1 (3.8%) |
Lead associated | 2 (7.7%) |
Mitral Regurgitation | |
Mild | 11 (42.3%) |
Moderate | 7 (26.9%) |
Moderate-Severe | 3 (11.5%) |
Aortic Regurgitation | |
Mild | 13 (50.0%) |
Moderate | 4 (15.4%) |
Severe | 0 (0%) |
Parameters | All Patients (n = 26) |
---|---|
Clip (n) | |
1 | 2 (7.7%) |
2 | 22 (84.6%) |
3 | 2 (7.69%) |
A-S | 76.9% |
P-S | 15.4% |
A-P-S | 7.7% |
A-P | 0% |
Success | 26 (100%) |
Complications | 2 (7.7%) |
Death | 0 |
Hospitalization Length (days) | 5 |
Parameters | All Patients (n = 26) |
---|---|
Tricuspid regurgitation | |
Mild | 6 (23.1%) |
Moderate | 18 (69.2%) |
Severe | 2 (7.7%) |
TAPSE (mm) | 17.29 ± 3.58 |
PAPS (mmHg) | 44.04 ± 12.85 |
EF (%) | 59.96 ± 8.83 |
Parameters | Before | After | p Value |
---|---|---|---|
SL diameter (cm) | 4.09 ± 0.44 | 3.54 ± 0.53 | <0.0001 |
AP diameter (cm) | 4.29 ± 0.79 | 4.01 ± 0.62 | 0.0626 |
Major diameter (cm) | 4.65 ± 0.63 | 4.28 ± 0.65 | 0.0002 |
Area (cmq) | 14.00 ± 2.91 | 11.25 ± 2.91 | <0.0001 |
Perimeter (cm) | 13.62 ± 1.43 | 12.42 ± 1.62 | <0.0001 |
Eccentricity Index | 0.98 ± 0.17 | 0.90 ± 0.17 | 0.0286 |
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Widmann, M.; Nerla, R.; Castriota, F.; Fisicaro, A.; De Luca, V.M.; Pesarini, G.; Ribichini, F.L.; Squeri, A. Impact of Transcatheter Edge-to-Edge Repair on Tricuspid Annular Remodeling in Patients with Tricuspid Regurgitation. J. Clin. Med. 2025, 14, 5606. https://doi.org/10.3390/jcm14155606
Widmann M, Nerla R, Castriota F, Fisicaro A, De Luca VM, Pesarini G, Ribichini FL, Squeri A. Impact of Transcatheter Edge-to-Edge Repair on Tricuspid Annular Remodeling in Patients with Tricuspid Regurgitation. Journal of Clinical Medicine. 2025; 14(15):5606. https://doi.org/10.3390/jcm14155606
Chicago/Turabian StyleWidmann, Maddalena, Roberto Nerla, Fausto Castriota, Andrea Fisicaro, Valeria Maria De Luca, Gabriele Pesarini, Flavio Luciano Ribichini, and Angelo Squeri. 2025. "Impact of Transcatheter Edge-to-Edge Repair on Tricuspid Annular Remodeling in Patients with Tricuspid Regurgitation" Journal of Clinical Medicine 14, no. 15: 5606. https://doi.org/10.3390/jcm14155606
APA StyleWidmann, M., Nerla, R., Castriota, F., Fisicaro, A., De Luca, V. M., Pesarini, G., Ribichini, F. L., & Squeri, A. (2025). Impact of Transcatheter Edge-to-Edge Repair on Tricuspid Annular Remodeling in Patients with Tricuspid Regurgitation. Journal of Clinical Medicine, 14(15), 5606. https://doi.org/10.3390/jcm14155606