The Role of Obstructive Sleep Apnea in Pulmonary Hypertension Associated with Lung Diseases (Group 3 Pulmonary Hypertension): A Narrative Review
Abstract
1. Introduction
2. Updates in WHO Group 3 Pulmonary Hypertension
3. Obstructive Sleep Apnea and Patients with Pulmonary Hypertension Associated with Pulmonary Diseases (WHO gr. 3 PH)
4. Obstructive Sleep Apnea as a Primary Etiology of Pulmonary Hypertension
5. Effects of Therapeutic Strategies on Pulmonary Artery Pressure and Obstructive Sleep Apnea in WHO Group 3 PH
5.1. Positive Airway Pressure Therapy
5.2. Oxygen Therapy
5.3. PAH-Targeted Drugs
5.4. Lung Transplant
5.5. Pulmonary and Cardiac Rehabilitation
5.6. Weight Management
5.7. Treatment of Volume Overload
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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6th WSPH Group 3 Pulmonary Hypertension [10] | 7th WSPH Group 3 Pulmonary Hypertension [14] |
---|---|
Obstructive lung disease or emphysema Restrictive lung disease Lung diseases with mixed restrictive/obstructive patterns Hypoxia without lung diseases Developmental lung disorders | COPD and/or emphysema Interstitial lung disease Combined pulmonary fibrosis and emphysema Other parenchymal lung diseases Nonparenchymal restrictive diseases:
Developmental lung diseases |
Obstructive sleep apnea |
Positive airway pressure therapy |
Weight management (medical, surgical, lifestyle) Treatment of volume overload |
WHO Group 3 PH |
Optimize treatment of primary pulmonary diagnoses Long-term oxygen therapy if severe daytime hypoxemia Inhaled Treprostinil with PH-ILD |
Pulmonary/cardiac rehabilitation Lung transplantation Weight management (medical, surgical, lifestyle) |
Treatment of volume overload |
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Tripipitsiriwat, A.; Malhotra, A.; Robertson, H.; Kim, N.H.; Yang, J.Z.; Raphelson, J. The Role of Obstructive Sleep Apnea in Pulmonary Hypertension Associated with Lung Diseases (Group 3 Pulmonary Hypertension): A Narrative Review. J. Clin. Med. 2025, 14, 5442. https://doi.org/10.3390/jcm14155442
Tripipitsiriwat A, Malhotra A, Robertson H, Kim NH, Yang JZ, Raphelson J. The Role of Obstructive Sleep Apnea in Pulmonary Hypertension Associated with Lung Diseases (Group 3 Pulmonary Hypertension): A Narrative Review. Journal of Clinical Medicine. 2025; 14(15):5442. https://doi.org/10.3390/jcm14155442
Chicago/Turabian StyleTripipitsiriwat, Athiwat, Atul Malhotra, Hannah Robertson, Nick H. Kim, Jenny Z. Yang, and Janna Raphelson. 2025. "The Role of Obstructive Sleep Apnea in Pulmonary Hypertension Associated with Lung Diseases (Group 3 Pulmonary Hypertension): A Narrative Review" Journal of Clinical Medicine 14, no. 15: 5442. https://doi.org/10.3390/jcm14155442
APA StyleTripipitsiriwat, A., Malhotra, A., Robertson, H., Kim, N. H., Yang, J. Z., & Raphelson, J. (2025). The Role of Obstructive Sleep Apnea in Pulmonary Hypertension Associated with Lung Diseases (Group 3 Pulmonary Hypertension): A Narrative Review. Journal of Clinical Medicine, 14(15), 5442. https://doi.org/10.3390/jcm14155442