Next Article in Journal
The Efficacy of the RME II System Compared with the Sander Bite-Jumping Appliance: A Retrospective Study
Previous Article in Journal
AI-Based Predictive Models for Cardiogenic Shock in STEMI: Real-World Data for Early Risk Assessment and Prognostic Insights
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 14
Issue 11
10.3390/jcm14113696
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Management of Systemic Cardiotoxicity Associated with Antidepressant Use in Patients with Depressive Disorders: A Systematic Review

by
Omar Anwar Saleh Al Nakhebi
1,*,
Raluka Albu-Kalinovic
1,
Adela Bosun
1,
Oana Neda-Stepan
1,
Marius Gliga
1,
Cătălina-Angela Crișan
2,
Ileana Marinescu
3 and
Virgil-Radu Enătescu
4
1
Doctoral School, University of Medicine and Pharmacy Victor Babes Timisoara, 300041 Timisoara, Romania
2
Department of Neurosciences, Discipline of Psychiatry and Pediatric Psychiatry, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania
3
Discipline of Psychiatry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
4
Discipline of Psychiatry, Department of Neurosciences, University of Medicine and Pharmacy Victor Babes Timisoara, 300041 Timisoara, Romania
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(11), 3696; https://doi.org/10.3390/jcm14113696
Submission received: 13 April 2025 / Revised: 14 May 2025 / Accepted: 23 May 2025 / Published: 25 May 2025
(This article belongs to the Section Pharmacology)
Versions Notes

Abstract

Background: Depression is one of the leading causes of disability worldwide, with a significant impact on individuals’ quality of life. The use of antidepressants is fundamental in the treatment of this condition; however, it is essential to recognize that the use of these drugs can be associated with adverse effects, including cardiotoxicity. Methods: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a literature search was conducted of the PubMed/Medline, Scopus, and Cochrane databases. Twenty studies were included in the final quantitative analysis. The Joanna Briggs Institute critical appraisal tool was used to assess the risk of bias. Results: It is possible to highlight a correlation between intake of antidepressants and development of cardiotoxicity. Analysis of the selected studies allows for an understanding of the importance of a multidisciplinary approach for the protection of these patients. Conclusions: Management of antidepressant-induced cardiotoxicity requires a thorough understanding of the pathophysiological mechanisms involved and a critical evaluation of the various therapeutic strategies available to promote clinical practice.
Keywords: cardiotoxicity; antidepressive agents cardiotoxicity; antidepressive agents

Share and Cite

MDPI and ACS Style

Al Nakhebi, O.A.S.; Albu-Kalinovic, R.; Bosun, A.; Neda-Stepan, O.; Gliga, M.; Crișan, C.-A.; Marinescu, I.; Enătescu, V.-R. Management of Systemic Cardiotoxicity Associated with Antidepressant Use in Patients with Depressive Disorders: A Systematic Review. J. Clin. Med. 2025, 14, 3696. https://doi.org/10.3390/jcm14113696

AMA Style

Al Nakhebi OAS, Albu-Kalinovic R, Bosun A, Neda-Stepan O, Gliga M, Crișan C-A, Marinescu I, Enătescu V-R. Management of Systemic Cardiotoxicity Associated with Antidepressant Use in Patients with Depressive Disorders: A Systematic Review. Journal of Clinical Medicine. 2025; 14(11):3696. https://doi.org/10.3390/jcm14113696

Chicago/Turabian Style

Al Nakhebi, Omar Anwar Saleh, Raluka Albu-Kalinovic, Adela Bosun, Oana Neda-Stepan, Marius Gliga, Cătălina-Angela Crișan, Ileana Marinescu, and Virgil-Radu Enătescu. 2025. "Management of Systemic Cardiotoxicity Associated with Antidepressant Use in Patients with Depressive Disorders: A Systematic Review" Journal of Clinical Medicine 14, no. 11: 3696. https://doi.org/10.3390/jcm14113696

APA Style

Al Nakhebi, O. A. S., Albu-Kalinovic, R., Bosun, A., Neda-Stepan, O., Gliga, M., Crișan, C.-A., Marinescu, I., & Enătescu, V.-R. (2025). Management of Systemic Cardiotoxicity Associated with Antidepressant Use in Patients with Depressive Disorders: A Systematic Review. Journal of Clinical Medicine, 14(11), 3696. https://doi.org/10.3390/jcm14113696

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop