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10.3390/jcm13082179
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Background:
Systematic Review

Topical Agents in Biofilm Disaggregation: A Systematic Review and Meta-Analysis

by
Alessia Pardo
,
Vera Fiorini
,
Alessandro Zangani
*,
Paolo Faccioni
,
Annarita Signoriello
,
Massimo Albanese
and
Giorgio Lombardo
Section of Oral and Maxillofacial Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37124 Verona, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(8), 2179; https://doi.org/10.3390/jcm13082179
Submission received: 19 March 2024 / Revised: 2 April 2024 / Accepted: 8 April 2024 / Published: 10 April 2024
(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
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Abstract

Background: to evaluate the effectiveness of different topical agents in biofilm disaggregation during non-surgical periodontal therapy. Methods: the search strategy was conducted according to the PRISMA 2020 on Pubmed, Cochrane Library, Scopus, and Web of Science, and it was registered in PROSPERO, ID: CRD42023474232. It included studies comparing non-surgical periodontal therapy (NSPT) with and without the application of topical agents for biofilm disruption. A risk of bias analysis, a qualitative analysis, and a quantitative analysis were performed. Results: out of 1583 records, 11 articles were included: 10 randomized clinical trials and one retrospective analysis. The total number of participants considered in the 11 articles included in the study was 386. The primary outcomes were probing pocket depth (PPD), clinical attachment level (CAL), and bleeding indices. The secondary outcomes were plaque indices, gingival recessions, and microbiological parameters. The meta-analysis revealed the following: [Weighted mean difference (WMD): −0.37; 95% confidence interval (CI) (−0.62, −0.12), heterogeneity I2: 79%, statistical significance p = 0.004]. Conclusions: the meta-analysis of probing pocket depth reduction (PPD) between baseline and follow-up at 3–6 months showed a statistically significant result in favor of sulfonated phenolics gel. The scientific evidence is still limited and heterogeneous; further randomized clinical trials are required.
Keywords: periodontitis; periodontal debridement; adjunctive therapy; desiccant agent; desiccation; sodium hypochlorite periodontitis; periodontal debridement; adjunctive therapy; desiccant agent; desiccation; sodium hypochlorite

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MDPI and ACS Style

Pardo, A.; Fiorini, V.; Zangani, A.; Faccioni, P.; Signoriello, A.; Albanese, M.; Lombardo, G. Topical Agents in Biofilm Disaggregation: A Systematic Review and Meta-Analysis. J. Clin. Med. 2024, 13, 2179. https://doi.org/10.3390/jcm13082179

AMA Style

Pardo A, Fiorini V, Zangani A, Faccioni P, Signoriello A, Albanese M, Lombardo G. Topical Agents in Biofilm Disaggregation: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2024; 13(8):2179. https://doi.org/10.3390/jcm13082179

Chicago/Turabian Style

Pardo, Alessia, Vera Fiorini, Alessandro Zangani, Paolo Faccioni, Annarita Signoriello, Massimo Albanese, and Giorgio Lombardo. 2024. "Topical Agents in Biofilm Disaggregation: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 13, no. 8: 2179. https://doi.org/10.3390/jcm13082179

APA Style

Pardo, A., Fiorini, V., Zangani, A., Faccioni, P., Signoriello, A., Albanese, M., & Lombardo, G. (2024). Topical Agents in Biofilm Disaggregation: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 13(8), 2179. https://doi.org/10.3390/jcm13082179

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