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Volume 13
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10.3390/jcm13030773
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Article

Early Impact of Mobilization Process on Cardiac Function and Size in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation

by
Audrone Vaitiekiene
1,*,
Migle Kulboke
2,
Monika Bieseviciene
1,
Agne Bartnykaite
3,
Benas Kireilis
4,
Diana Rinkuniene
5,
Antanas Jankauskas
6,7,
Justinas Zemaitis
1,
Ignas Gaidamavicius
2,
Rolandas Gerbutavicius
2,
Domas Vaitiekus
2,
Jolanta Justina Vaskelyte
1,7 and
Gintare Sakalyte
1,7
1
Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania
2
Department of Oncology and Hematology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania
3
Oncology Research Laboratory, Oncology Institute, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania
4
Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania
5
Institute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania
6
Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania
7
Institute of Cardiology, Lithuanian University of Health Sciences, 47181 Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(3), 773; https://doi.org/10.3390/jcm13030773
Submission received: 14 December 2023 / Revised: 17 January 2024 / Accepted: 26 January 2024 / Published: 29 January 2024
(This article belongs to the Section Hematology)
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Abstract

Background: The hematopoietic stem cell transplantation (HSCT) process is known to cause cardiac toxicity of different grades. In this paper, we aimed to evaluate the impact of mobilization procedure of hematopoietic stem cells for autologous HSCT process for left and right ventricle sizes and functions. Material and Methods: The data of 47 patients undergoing autologous HSCT were analyzed. All patients underwent hematopoietic stem cell mobilization with chemotherapy and filgrastim at 10 µg/kg/d. Echocardiography was performed two times: before enrolling in the transplantation process and after mobilization before the conditioning regimen for transplantation. Changes in left and right ventricle (RV) diameter and systolic and diastolic function of the left ventricle and systolic function of the RV were measured. Results: A statistically significant difference was observed in the change of right ventricular function (S‘)—it slightly decreased. Mean S‘ before mobilization was 13.93 ± 2.85 cm/s, and after mobilization it was 12.19 ± 2.64 cm/s (p = 0.003). No statistically significant change in left ventricular diameter and systolic and diastolic function and RV diameter was observed. Conclusions: The mobilization procedure in patients undergoing autologous HSCT is associated with reduced RV systolic function. S‘ could be used as a reliable tool to evaluate early cardiotoxicity in HSCT patients and guide further follow-up.
Keywords: autologous hematopoietic stem cell transplantation; cardiotoxicity; mobilization autologous hematopoietic stem cell transplantation; cardiotoxicity; mobilization
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MDPI and ACS Style

Vaitiekiene, A.; Kulboke, M.; Bieseviciene, M.; Bartnykaite, A.; Kireilis, B.; Rinkuniene, D.; Jankauskas, A.; Zemaitis, J.; Gaidamavicius, I.; Gerbutavicius, R.; et al. Early Impact of Mobilization Process on Cardiac Function and Size in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation. J. Clin. Med. 2024, 13, 773. https://doi.org/10.3390/jcm13030773

AMA Style

Vaitiekiene A, Kulboke M, Bieseviciene M, Bartnykaite A, Kireilis B, Rinkuniene D, Jankauskas A, Zemaitis J, Gaidamavicius I, Gerbutavicius R, et al. Early Impact of Mobilization Process on Cardiac Function and Size in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation. Journal of Clinical Medicine. 2024; 13(3):773. https://doi.org/10.3390/jcm13030773

Chicago/Turabian Style

Vaitiekiene, Audrone, Migle Kulboke, Monika Bieseviciene, Agne Bartnykaite, Benas Kireilis, Diana Rinkuniene, Antanas Jankauskas, Justinas Zemaitis, Ignas Gaidamavicius, Rolandas Gerbutavicius, and et al. 2024. "Early Impact of Mobilization Process on Cardiac Function and Size in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation" Journal of Clinical Medicine 13, no. 3: 773. https://doi.org/10.3390/jcm13030773

APA Style

Vaitiekiene, A., Kulboke, M., Bieseviciene, M., Bartnykaite, A., Kireilis, B., Rinkuniene, D., Jankauskas, A., Zemaitis, J., Gaidamavicius, I., Gerbutavicius, R., Vaitiekus, D., Vaskelyte, J. J., & Sakalyte, G. (2024). Early Impact of Mobilization Process on Cardiac Function and Size in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation. Journal of Clinical Medicine, 13(3), 773. https://doi.org/10.3390/jcm13030773

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