Differences between SCORE, Framingham Risk Score, and Estimated Pulse Wave Velocity-Based Vascular Age Calculation Methods Based on Data from the Three Generations Health Program in Hungary
Abstract
:1. Introduction
2. Materials and Methods
2.1. Three Generations for Health Program
2.2. Calculation of Vascular Age Using the Framingham Risk Score
2.3. Calculation of Vascular Age Using the Systematic Coronary Risk Evaluation (SCORE) Risk Score
2.4. Calculation of ePWV
2.5. Supernormal, Normal, and Early Vascular Ageing
2.6. Statistical Analysis
3. Results
- -
- Age difference < −2 years: SCORE−, FRS−: supernormal vascular ageing;
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- Age difference between −2 and 2 years: SCORE normal, FRS normal: normal vascular ageing;
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- Age difference > 2 years: SCORE+, FRS+: early vascular ageing.
4. Discussion
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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n | 99,231 |
Age (years) | 54.0 (48.0–60.0) |
Men (%) | 40,443 (40.8) |
Women (%) | 58,788 (59.2) |
Hypertension (%) | 49,191 (49.6) |
Diabetes (%) | 15,921 (16.0) |
Smoking (%) | 28,956 (29.2) |
Systolic BP (mmHg) | 130.0 (122.0–130.0) |
Diastolic BP (mmHg) | 80.0 (76.0–86.0) |
ePWV (m/s) | 9.0 (8.1–10.0) |
Cholesterol (mmol/L) | 5.4 (4.7–6.2) |
HDL-cholesterol (mmol/L) | 1.4 (1.2–1.7) |
Supernormal Vascular Aging | Normal Vascular Aging | Early Vascular Aging | |
---|---|---|---|
N (%) | 10,557 (10.6) | 78,855 (79.5) | 9819 (9.9) |
Men (%) | 2671 (25.3) | 32,703 (41.5) | 5069 (51.6) |
Women (%) | 7886 (74.7) | 46,152 (58.5) | 4750 (48.4) |
Chronological age (years) | 51.0 (45.0–60.0) | 54.0 (48.0–61.0) | 57.0 (48.0–62.0) |
SCORE vascular age (years) | 52.0 (46.0–60.0) | 59.0 (51.0–66.0) | 67.00 (58.0–74.0) |
FRS vascular age (years) | 59.0 (48.0–80.0) | 64.0 (51.0–80.0) | 80.0 (68.0–80.0) |
ePWV (m/s) | 7.80 (6.9–8.7) | 9.0 (8.2–9.9) | 10.6 (9.80–11.5) |
Hypertension (%) | 2892 (27.4) | 39,436 (50.0) | 6863 (69.9) |
Diabetes (%) | 935 (8.9) | 12,936 (16.4) | 2050 (20.9) |
No hypertension or diabetes (%) | 7375 (69.8) | 36,757 (46.6) | 2718 (27.7) |
Smoking (%) | 2844 (26.9) | 22,851 (29.0) | 3261 (33.2) |
Systolic BP (mmHg) | 115.0 (110.0–120.0) | 130.0 (125.0–140.0) | 157.0 (150.0–167.0) |
Diastolic BP (mmHg) | 70.0 (67.0–72.0) | 80.0 (78.0–85.0) | 95.00 (90.0–100.0) |
Cholesterol (mmol/L) | 5.3 (4.6–6.1) | 5.4 (4.7–6.2) | 5.60 (4.81–6.40) |
HDL-cholesterol (mmol/L) | 1.5 (1.2–1.8) | 1.40 (1.2–1.7) | 1.4 (1.2–1.7) |
Supernormal Vascular Aging | Normal Vascular Aging | Early Vascular Aging | |
---|---|---|---|
FRS− (n %) | 5521 (52.3) | 13,077 (16.6) | 61 (0.1) |
FRS normal (n %) | 1554 (14.7) | 8854 (11.2) | 200 (0.6) |
FRS+ (n %) | 3482 (33) | 56,924 (72.2) | 9558 (97.3) |
SCORE− (n %) | 2776 (26.3) | 47,742 (60.5) | 6915 (70.4) |
SCORE normal (n %) | 1868 (17.7) | 13,742 (17.4) | 1600 (16.3) |
SCORE+ (n %) | 5913 (56.0) | 17,371 (22.1) | 1304 (13.3) |
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Gyöngyösi, H.; Szőllősi, G.J.; Csenteri, O.; Jancsó, Z.; Móczár, C.; Torzsa, P.; Andréka, P.; Vajer, P.; Nemcsik, J. Differences between SCORE, Framingham Risk Score, and Estimated Pulse Wave Velocity-Based Vascular Age Calculation Methods Based on Data from the Three Generations Health Program in Hungary. J. Clin. Med. 2024, 13, 205. https://doi.org/10.3390/jcm13010205
Gyöngyösi H, Szőllősi GJ, Csenteri O, Jancsó Z, Móczár C, Torzsa P, Andréka P, Vajer P, Nemcsik J. Differences between SCORE, Framingham Risk Score, and Estimated Pulse Wave Velocity-Based Vascular Age Calculation Methods Based on Data from the Three Generations Health Program in Hungary. Journal of Clinical Medicine. 2024; 13(1):205. https://doi.org/10.3390/jcm13010205
Chicago/Turabian StyleGyöngyösi, Helga, Gergő József Szőllősi, Orsolya Csenteri, Zoltán Jancsó, Csaba Móczár, Péter Torzsa, Péter Andréka, Péter Vajer, and János Nemcsik. 2024. "Differences between SCORE, Framingham Risk Score, and Estimated Pulse Wave Velocity-Based Vascular Age Calculation Methods Based on Data from the Three Generations Health Program in Hungary" Journal of Clinical Medicine 13, no. 1: 205. https://doi.org/10.3390/jcm13010205
APA StyleGyöngyösi, H., Szőllősi, G. J., Csenteri, O., Jancsó, Z., Móczár, C., Torzsa, P., Andréka, P., Vajer, P., & Nemcsik, J. (2024). Differences between SCORE, Framingham Risk Score, and Estimated Pulse Wave Velocity-Based Vascular Age Calculation Methods Based on Data from the Three Generations Health Program in Hungary. Journal of Clinical Medicine, 13(1), 205. https://doi.org/10.3390/jcm13010205