Multimodality Cardiac Imaging in Young and Veteran Athletes: Updates on Atrial Function Assessment, Arrhythmia Predisposition and Pathology Discrimination
1
Sports Cardiology & Inherited Cardiac Conditions Department, St George’s Hospital NHS Foundation Trust, London SW17 0QT, UK
2
Cardiac Rehabilitation Unit, Rehabilitation Clinic “Villa delle Magnolie”, Castel Morrone, 81020 Caserta, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2023, 12(3), 797; https://doi.org/10.3390/jcm12030797
Submission received: 9 January 2023
/
Accepted: 17 January 2023
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Published: 19 January 2023
(This article belongs to the Section Cardiology)
Sports physicians and physiologists have aimed to assess exercise in young and master athletes so as to work out their conditioning levels and design training programs accordingly. Cardiopulmonary exercise testing (CPET) provides a thorough assessment of the physiologic responses of the pulmonary, cardiovascular, muscular, and cellular oxidative systems to exercise in both athletic individuals and those with cardiovascular conditions, and has been used successfully to assess post-COVID-19 infection sequelae in competitive athletes [1,2,3].
On the other hand, athletic training is known to induce morphological and functional cardiovascular adaptations of both ventricles and atria, collectively known as athlete’s heart. Apart from advanced echocardiographic methods, cardiac magnetic resonance (CMR) is an imaging modality with a high spatial resolution and no exposure to ionizing radiation, and has the benefit of tissue characterization by exploiting gadolinium-based contrast late enhancement as a marker of myocardial fibrosis. Its additional novel developments in tissue characterization, particularly in the last 5–10 years, have been increasingly used in clinical practice in pathology discrimination, particularly with inherited cardiomyopathy. These may provide an accurate diagnosis in challenging cases and may differentiate from various pathologies, but, at the same time, provide insights into atrial structure, function, and future risk of atrial and ventricular arrhythmia [4].
More specifically, biatrial function was estimated by peak atrial longitudinal and contraction strains, before and after races in master athletes. The results of a cross-sectional study by the group of D’Ascenzi in Italy did not confirm the hypothesis of acute atrial dysfunction induced by ultra-endurance exercise, even though one athlete developed atrial fibrillation during the race [5]. Furthermore, observational data from Zürich, based on patients with definite arrhythmogenic right ventricular cardiomyopathy (ARVC) compared with athletes, showed that ARVC patients present with a significantly larger right atrial volume index (RAVI) compared to athletes, resulting in a greater RAVI/LAVI ratio. Based on an ROC analysis, a score was developed that included the following parameters: indexed right/left atrial volume ratio (RAVI/LAVI ratio), NT-proBNP, RV outflow tract measurements, tricuspid annular motion, precordial T-wave inversion, and depolarization abnormalities according to 2010 Task Force Criteria. A score of 6/12 points yielded a specificity of 91% and an improved sensitivity of 67% for ARVC diagnosis as compared to a sensitivity of 41% for the Task Force Criteria [6].
Moreover, in a single-center study, again from Switzerland, 12-lead ECG, signal-averaged ECG, 24 h Holter ECG, and advanced left atrial echocardiographic data were prospectively collected in patients with hypertrophic cardiomyopathy, hypertensive disease, and endurance athletes. Structural and electrical atrial remodeling is more advanced in hypertrophic cardiomyopathy compared to hypertensive disease and endurance athletes [7]. Another recent advance which might play an important role in imaging diagnostics is HyperDoppler. It is a new echocardiographic color Doppler-based technique that can assess intracardiac flow dynamics. A feasibility and reproducibility study of this technique was recently performed on unselected patients, and its capability to differentiate measures of vortex flow within the left ventricle (LV) in normal sedentary subjects, athletes, and patients with heart failure was assessed. It was shown that HyperDoppler is a feasible, reliable, and practical technique for the assessment of LV flow dynamics, and may distinguish between normal subjects and patients with heart failure [8].
Lastly, and quite importantly, the Italian group from Padova by Corrado et al. has summarized important recent work on the diagnostic assessment of athletes with premature ventricular beats (PVBs) and contrast-enhanced CMR imaging. The morphology, complexity, and exercise inducibility of PVBs can help estimate the probability of an underlying heart disease. Based on these features, the CMR imaging and assessment of non-ischemic scars, as well as their patterns and extent, may be indicated even when echocardiography is normal [9].
Author Contributions
Conceptualization, E.A. and F.P.; Writing—original draft preparation, E.A.; writing—review and editing, E.A. and F.P. All authors have read and agreed to the published version of the manuscript.
Funding
This research received no external funding.
Conflicts of Interest
The authors declare no conflict of interest.
References
- Briasoulis, A.; Theodorakakou, F.; Rempakos, A.; Petropoulos, I.; Gavriatopoulou, M.; Androulakis, E.; Stamatelopoulos, K.; Kallianos, A.; Trakada, G.; Dimopoulos, M.A.; et al. Cardiopulmonary exercise physiology in AL amyloidosis patients with cardiac involvement and its association with cardiac imaging parameters. J. Clin. Med. 2022, 11, 5437. [Google Scholar] [CrossRef] [PubMed]
- Mazaheri, R.; Christian Schmied, C.; Niederseer, D.; Guazzi, M. Cardiopulmonary exercise test parameters in athletic population: A Review. J. Clin. Med. 2021, 10, 5073. [Google Scholar] [CrossRef] [PubMed]
- Klara Komici, K.; Bianco, A.; Perrotta, F.; Dello Iacono, A.; Bencivenga, L.; D’Agnano, V.; Rocca, A.; Bianco, A.; Rengo, G.; Guerra, G. Clinical characteristics, exercise capacity and pulmonary function in post-COVID-19 competitive athletes. J. Clin. Med. 2021, 10, 3053. [Google Scholar] [CrossRef]
- D’Andrea, A.; Sperlongano, S.; Russo, V.; D’Ascenzi, F.; Benfari, G.; Renon, F.; Palermi, S.; Ilardi, F.; Giallauria, F.; Limongelli, G.; et al. The Role of Multimodality Imaging in Athlete’s Heart Diagnosis: Current Status and Future Directions. J. Clin. Med. 2021, 10, 5126. [Google Scholar] [CrossRef]
- Cavigli, L.; Zorzi, A.; Spadotto, V.; Mandoli, G.E.; Melani, A.; Fusi, C.; D’Andrea, A.; Focardi, M.; Valente, S.; Cameli, M.; et al. The acute effects of an ultramarathon on atrial function and supraventricular arrhythmias in master athlete. J. Clin. Med. 2022, 11, 528. [Google Scholar] [CrossRef] [PubMed]
- Rossi, V.A.; Niederseer, D.; Sokolska, J.M.; Kovacs, B.; Costa, S.; Gasperetti, A.; Brunckhorst, C.; Akdis, D.; Tanner, F.C.; Duru, F.; et al. A Novel diagnostic score integrating atrial dimensions to differentiate between the athlete’s heart and arrhythmogenic right ventricular cardiomyopathy. J. Clin. Med. 2021, 10, 4094. [Google Scholar] [CrossRef] [PubMed]
- Servatius, H.; Raab, S.; Asatryan, B.; Haeberlin, A.; Branca, M.; de Marchi, S.; Brugger, N.; Nozica, N.; Goulouti, E.; Elchinova, E.; et al. Differences in atrial remodeling in hypertrophic cardiomyopathy compared to hypertensive heart disease and athletes’ hearts. J. Clin. Med. 2022, 11, 1316. [Google Scholar] [CrossRef]
- Fiorencis, A.; Pepe, M.; Smarrazzo, V.; Martini, M.; Severino, S.; Pergola, V.; Evangelista, M.; Incarnato, P.; Previtero, M.; Maglione, M.; et al. Noninvasive evaluation of intraventricular flow dynamics by the hyperdoppler technique: First application to normal subjects, athletes, and patients with heart failure. J. Clin. Med. 2022, 11, 2216. [Google Scholar] [CrossRef]
- Brunetti, G.; Cipriani, A.; Perazzolo Marra, M.; De Lazzari, M.; Bauce, B.; Calore, C.; Rigato, I.; Graziano, F.; Vio, R.; Corrado, D.; et al. Role of Cardiac Magnetic Resonance Imaging in the Evaluation of Athletes with Premature Ventricular Beats. J. Clin. Med. 2022, 11, 426. [Google Scholar] [CrossRef] [PubMed]
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MDPI and ACS Style
Androulakis, E.; Perone, F. Multimodality Cardiac Imaging in Young and Veteran Athletes: Updates on Atrial Function Assessment, Arrhythmia Predisposition and Pathology Discrimination. J. Clin. Med. 2023, 12, 797. https://doi.org/10.3390/jcm12030797
AMA Style
Androulakis E, Perone F. Multimodality Cardiac Imaging in Young and Veteran Athletes: Updates on Atrial Function Assessment, Arrhythmia Predisposition and Pathology Discrimination. Journal of Clinical Medicine. 2023; 12(3):797. https://doi.org/10.3390/jcm12030797
Chicago/Turabian StyleAndroulakis, Emmanuel, and Francesco Perone. 2023. "Multimodality Cardiac Imaging in Young and Veteran Athletes: Updates on Atrial Function Assessment, Arrhythmia Predisposition and Pathology Discrimination" Journal of Clinical Medicine 12, no. 3: 797. https://doi.org/10.3390/jcm12030797
APA StyleAndroulakis, E., & Perone, F. (2023). Multimodality Cardiac Imaging in Young and Veteran Athletes: Updates on Atrial Function Assessment, Arrhythmia Predisposition and Pathology Discrimination. Journal of Clinical Medicine, 12(3), 797. https://doi.org/10.3390/jcm12030797
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