A Review of Therapeutic Drug Monitoring in Patients with Inflammatory Bowel Disease Receiving Combination Therapy
Abstract
:1. Introduction
2. Methodology
3. Therapeutic Drug Monitoring Strategies in Inflammatory Bowel Disease
4. Evidence for TDM in Combination Therapy
5. Role of TDM When Restarting Anti-TNFs after a Drug Holiday
TDM and De-Escalation of Combination Therapy
6. Discussion
7. Conclusions
Limitations
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Study Name/Reference | Study Design | Population | Intervention | Key Findings |
---|---|---|---|---|
TAXIT [28] | Randomized trial | IBD patients on infliximab | Proactive TDM vs. as-needed dose adjustment | Proactive TDM was not superior |
TAILORIX [29,30] | Randomized trial | IBD patients on infliximab | Proactive TDM | Results similar to TAXIT |
PAILOT [31] | Non-blinded RCT | Pediatric CD patients on adalimumab | Proactive dose adjustment | More efficacious than reactive approach |
NOR-DRUM A and B [32,33] | Randomized study | IBD patients on various treatments | Proactive TDM | No benefit during induction but beneficial during maintenance |
Study Name/Reference | Study Design | Population | Intervention | Key Findings |
---|---|---|---|---|
SONIC [19] | Randomized trial | CD patients on infliximab and azathioprine | Monotherapy vs. combination | Lower immunogenicity, and combination therapy superior |
UC-SUCCESS [57] | Randomized trial | UC patients on infliximab and azathioprine | Monotherapy vs. combination | Results similar to SONIC |
COMMIT [58] | Randomized trial | CD patients on infliximab and methotrexate | Monotherapy vs. combination | Lower immunogenicity but no significant difference in clinical outcomes |
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Patel, S.; Yarur, A.J. A Review of Therapeutic Drug Monitoring in Patients with Inflammatory Bowel Disease Receiving Combination Therapy. J. Clin. Med. 2023, 12, 6577. https://doi.org/10.3390/jcm12206577
Patel S, Yarur AJ. A Review of Therapeutic Drug Monitoring in Patients with Inflammatory Bowel Disease Receiving Combination Therapy. Journal of Clinical Medicine. 2023; 12(20):6577. https://doi.org/10.3390/jcm12206577
Chicago/Turabian StylePatel, Sanket, and Andres J. Yarur. 2023. "A Review of Therapeutic Drug Monitoring in Patients with Inflammatory Bowel Disease Receiving Combination Therapy" Journal of Clinical Medicine 12, no. 20: 6577. https://doi.org/10.3390/jcm12206577