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Article

Office-Based Intraosseous Infiltrations of PRGF as an Effective Treatment for Knee Osteoarthritis: A Retrospective Observational Clinical Study

by
Antonio Ríos Luna
1,*,
Homid Fahandezh-Saddi Díaz
2,
Manuel Villanueva Martínez
3,
Roberto Iglesias
1,
Roberto Prado
4,
Sabino Padilla
4 and
Eduardo Anitua
4
1
Department of Traumatology and Orthopedic Surgery, Clínica Orthoindal, 04004 Almería, Spain
2
Department of Orthopedic Surgery, Hospital Universitario Fundación Alcorcón, 28922 Alcorcón, Spain
3
Department of Traumatology and Orthopedic Surgery, Avanfi Institute, 28015 Madrid, Spain
4
Regenerative Medicine Laboratory, BTI—Biotechnology Institute I MAS D, 01007 Vitoria, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2023, 12(13), 4512; https://doi.org/10.3390/jcm12134512
Submission received: 15 June 2023 / Revised: 28 June 2023 / Accepted: 4 July 2023 / Published: 6 July 2023
(This article belongs to the Special Issue Osteoarthritis: Diagnosis and Therapeutic Approaches)
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Abstract

The aim of this study was to explore and assess office-based ultrasound-guided intraosseous and intra-articular infiltrations of plasma rich in growth factors (PRGF) in patients with moderate and severe knee osteoarthritis (KOA). Seventy-nine patients (30 women and 49 men) with grade 3–4 KOA according to the Kellgren–Lawrence classification participated in the study. All patients were treated with a minimally invasive technique using local anesthesia WALANT (wide-awake local anesthesia no tourniquet) in the ambulatory setting. A PRGF intra-articular infiltration and two intraosseous infiltrations in the tibial plateau and femoral condyle were performed weekly for a total of three sessions. The evaluation of the results was carried out using knee injury and osteoarthritis outcome score (KOOS) at baseline and post-treatment. After a follow-up period of 11 months (median) [interquartile range, 7–14], all the KOOS domains showed statistically significant improvement (p < 0.001). Moreover, 88% of the patients showed a pain reduction of at least 10 points (minimally clinically important improvement) from pre- to post-treatment. Our retrospective study using the in-office procedure of ultrasound-guided combination of intra-articular and intraosseous infiltrations of PRGF is a safe and efficacious approach for the treatment of grade 3–4 knee osteoarthritis.
Keywords: intraosseous; osteoarthritis; PRGF; platelet-rich plasma intraosseous; osteoarthritis; PRGF; platelet-rich plasma
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MDPI and ACS Style

Ríos Luna, A.; Fahandezh-Saddi Díaz, H.; Villanueva Martínez, M.; Iglesias, R.; Prado, R.; Padilla, S.; Anitua, E. Office-Based Intraosseous Infiltrations of PRGF as an Effective Treatment for Knee Osteoarthritis: A Retrospective Observational Clinical Study. J. Clin. Med. 2023, 12, 4512. https://doi.org/10.3390/jcm12134512

AMA Style

Ríos Luna A, Fahandezh-Saddi Díaz H, Villanueva Martínez M, Iglesias R, Prado R, Padilla S, Anitua E. Office-Based Intraosseous Infiltrations of PRGF as an Effective Treatment for Knee Osteoarthritis: A Retrospective Observational Clinical Study. Journal of Clinical Medicine. 2023; 12(13):4512. https://doi.org/10.3390/jcm12134512

Chicago/Turabian Style

Ríos Luna, Antonio, Homid Fahandezh-Saddi Díaz, Manuel Villanueva Martínez, Roberto Iglesias, Roberto Prado, Sabino Padilla, and Eduardo Anitua. 2023. "Office-Based Intraosseous Infiltrations of PRGF as an Effective Treatment for Knee Osteoarthritis: A Retrospective Observational Clinical Study" Journal of Clinical Medicine 12, no. 13: 4512. https://doi.org/10.3390/jcm12134512

APA Style

Ríos Luna, A., Fahandezh-Saddi Díaz, H., Villanueva Martínez, M., Iglesias, R., Prado, R., Padilla, S., & Anitua, E. (2023). Office-Based Intraosseous Infiltrations of PRGF as an Effective Treatment for Knee Osteoarthritis: A Retrospective Observational Clinical Study. Journal of Clinical Medicine, 12(13), 4512. https://doi.org/10.3390/jcm12134512

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