A Real-Life Study of Combined Treatment with Long-Term Non-Invasive Ventilation and High Flow Nasal Cannula in Patients with End-Stage Chronic Obstructive Lung Disease
Abstract
:1. Introduction
2. Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Total Study Population | |
---|---|
Sex (%female) | 60.6 |
Age (years) | 67.2 (7.1) |
MRC-score | 4.7 (0.3) |
FEV1, % | 28.6 (8.3) |
BMI (kg/m2) | 29.0 (5.8) |
Smoking status, present/former/never (%) | 33/67/0 |
Time between initiation of long-term oxygen therapy and respiratory support (months) | 31 (12.7) |
Number of hospitalizations twelve months before initiation of first respiratory support | 2.1 (1.6) |
Number of hospitalizations twelve months after initiation of first respiratory support | 1.6 (0.4) |
PaO2 at baseline (kPa) | 7.4 (0.82) |
PaCO2 at baseline (kPa) | 7.9 (1.42) |
HCO3 at baseline (mmol/L) | 32.5 (5.0) |
LT-NIV (N = 16) | LT-HFNC (N = 17) | p-Value | |
---|---|---|---|
Sex, (%female) | 56.2 | 65.0 | 0.72 |
Age (years) | 68.3 (7.5) | 66.8 (7.3) | 0.55 |
MRC-score | 4.8 (0.2) | 4.5 (0.5) | 0.92 |
FEV1% | 30.5 (8.8) | 27.1 (8.2) | 0.26 |
BMI | 28.9 (6.5) | 28.6 (5.5) | 0.68 |
Smoking status Present/former/never (%) | 25/75/0 | 35/65/0 | 0.23 |
PaO2 at initiation (kPa) | 7.2 (0.9) | 7.6 (2.1) | 0.24 |
PaCO2 at initiation(kPa) | 8.8 (0.9) | 7.1 (1.3) | 0.002 |
St. Bicarbonate at initiation (mmol/L) | 34.4 (5.4) | 30.7 (4.0) | 0.10 |
Number of hospitalizations twelve months before initiation of respiratory support | 2.9 (0.5) | 2.5 (0.4) | 0.13 |
Number of hospitalizations twelve months after initiation of respiratory support | 1.6 (0.4) | 1.5 (0.4) | 0.84 |
LT-HFNC as Second Device | LT-NIV as Second Device | |
---|---|---|
pO2, kPa | 6.9 (1.6) | 8.1 (1.1) |
pCO2, kPa | 8.2 (0.7) | 7.8 (1.1) |
St. Bicarbonate, mmol/L | 31.4 (3.4) | 32.1 (3.9) |
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Weinreich, U.M.; Storgaard, L.H. A Real-Life Study of Combined Treatment with Long-Term Non-Invasive Ventilation and High Flow Nasal Cannula in Patients with End-Stage Chronic Obstructive Lung Disease. J. Clin. Med. 2023, 12, 4485. https://doi.org/10.3390/jcm12134485
Weinreich UM, Storgaard LH. A Real-Life Study of Combined Treatment with Long-Term Non-Invasive Ventilation and High Flow Nasal Cannula in Patients with End-Stage Chronic Obstructive Lung Disease. Journal of Clinical Medicine. 2023; 12(13):4485. https://doi.org/10.3390/jcm12134485
Chicago/Turabian StyleWeinreich, Ulla Møller, and Line Hust Storgaard. 2023. "A Real-Life Study of Combined Treatment with Long-Term Non-Invasive Ventilation and High Flow Nasal Cannula in Patients with End-Stage Chronic Obstructive Lung Disease" Journal of Clinical Medicine 12, no. 13: 4485. https://doi.org/10.3390/jcm12134485
APA StyleWeinreich, U. M., & Storgaard, L. H. (2023). A Real-Life Study of Combined Treatment with Long-Term Non-Invasive Ventilation and High Flow Nasal Cannula in Patients with End-Stage Chronic Obstructive Lung Disease. Journal of Clinical Medicine, 12(13), 4485. https://doi.org/10.3390/jcm12134485