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Article

Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US

by
Liza Johannesson
1,2,*,
Giuliano Testa
1,
Menas M. Beshara
3,
Briget da Graca
1,
Jessica R. Walter
4,
Cristiano Quintini
5,
Nawar Latif
6,
Koji Hashimoto
7,
Elliott G. Richards
8 and
Kathleen O’Neill
9
1
Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USA
2
Department of Obstetrics and Gynecology, Baylor University Medical Center, Dallas, TX 75246, USA
3
TX A&M College of Medicine, Texas A&M University, Dallas, TX 75231, USA
4
Department of Obstetrics & Gynecology, Northwestern University, Chicago, IL 60611, USA
5
Department of General Surgery, Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates
6
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19107, USA
7
Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH 44103, USA
8
Obstetrics and Gynecology and Women’s Health Institute, Cleveland Clinic, Cleveland, OH 44103, USA
9
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19107, USA
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2023, 12(13), 4201; https://doi.org/10.3390/jcm12134201
Submission received: 10 May 2023 / Revised: 7 June 2023 / Accepted: 15 June 2023 / Published: 21 June 2023
(This article belongs to the Special Issue New Advances in Uterus and Ovarian Transplantation)
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Abstract

This study describes the characteristics of women who contacted an active program performing uterus transplantation (UTx) in the US, expressing interest in becoming a uterus transplant recipient or a living donor. Basic demographic and self-reported clinical information was collected from women who contacted any of the three US UTx programs from 2015 to July 2022. The three centers received 5194 inquiries about becoming a UTx recipient during the study timeframe. Among those reporting a cause of infertility, almost all of the reports (4066/4331, 94%) were absence of a uterus, either congenitally (794/4066, 20%) or secondary to hysterectomy (3272/4066, 80%). The mean age was 34 years, and 49% (2545/5194) had at least one child at the time of application. The two centers using living donors received 2217 inquiries about becoming living donors. The mean age was 34 years, and 60% (1330/2217) had given birth to ≥1 child. While most of the UTx clinical trial evidence has focused on young women with congenital absence of the uterus, these results show interest from a much broader patient population in terms of age, cause of infertility, and parity. These results raise questions about whether and to what extent the indications and eligibility criteria for UTx should be expanded as the procedure transitions from the experimental phase to being offered as a clinical treatment.
Keywords: uterus transplantation; recipient; living donor; hysterectomy; infertility; parity uterus transplantation; recipient; living donor; hysterectomy; infertility; parity

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MDPI and ACS Style

Johannesson, L.; Testa, G.; Beshara, M.M.; da Graca, B.; Walter, J.R.; Quintini, C.; Latif, N.; Hashimoto, K.; Richards, E.G.; O’Neill, K. Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US. J. Clin. Med. 2023, 12, 4201. https://doi.org/10.3390/jcm12134201

AMA Style

Johannesson L, Testa G, Beshara MM, da Graca B, Walter JR, Quintini C, Latif N, Hashimoto K, Richards EG, O’Neill K. Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US. Journal of Clinical Medicine. 2023; 12(13):4201. https://doi.org/10.3390/jcm12134201

Chicago/Turabian Style

Johannesson, Liza, Giuliano Testa, Menas M. Beshara, Briget da Graca, Jessica R. Walter, Cristiano Quintini, Nawar Latif, Koji Hashimoto, Elliott G. Richards, and Kathleen O’Neill. 2023. "Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US" Journal of Clinical Medicine 12, no. 13: 4201. https://doi.org/10.3390/jcm12134201

APA Style

Johannesson, L., Testa, G., Beshara, M. M., da Graca, B., Walter, J. R., Quintini, C., Latif, N., Hashimoto, K., Richards, E. G., & O’Neill, K. (2023). Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US. Journal of Clinical Medicine, 12(13), 4201. https://doi.org/10.3390/jcm12134201

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