Epidemiology and Clinical Characteristics Based on the Rome III and IV Criteria of Japanese Patients with Functional Dyspepsia
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Patients
2.3. Assessment
2.4. Questionnaires (Symptoms, QOL, Anxiety, and Depression)
2.5. Statistical Analysis
3. Results
3.1. Enrolment and Baseline Characteristics of the Patients
3.2. FD Subgroups under the Rome III Criteria vs. the Rome IV Criteria
3.3. Patient Background Factors for FD under the Rome III Criteria vs. the Rome IV Criteria
3.4. Characteristics of PDS to PDS vs. Overlap to PDS
3.5. QOL, Psychological Score, Gastrointestinal Symptoms (PDS to PDS vs. Overlap to PDS)
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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FD | Rome III | Rome IV | |||||
---|---|---|---|---|---|---|---|
Overlap PDS-EPS | PDS | EPS | Overlap PDS-EPS | PDS | EPS | ||
n | 111 | 48 | 42 | 21 | 19 | 71 | 21 |
Age (y) | 54.3 ± 14.9 | 51.8 ± 15.5 | 57.3 ± 12.4 | 53.8 ± 16.9 | 55.5 ± 13.1 | 54.1 ± 14.7 | 53.8 ± 16.9 |
Gender (% female) | 68.5 | 70.8 | 69 | 61.9 | 52.6 | 74.6 | 61.9 |
BMI (kg/m2) | 21.8 ± 3.5 | 22.2 ± 3.6 | 21.4 ± 3.7 | 21.9 ± 2.6 | 22.7 ± 4.1 | 21.6 ± 3.5 | 21.9 ± 2.6 |
Smoking | 23.4% | 25% | 16.7% | 33.3% | 31.6% | 18.3% | 33.3% |
Drinking | 28.8% | 27.1% | 19% | 52.4% | 26.3% | 22.5% | 52.4% |
After eradication of Helicobacter pylori | 22.5% | 22.9% | 14.3% | 33.3% | 26.3% | 18.3% | 33.3% |
Postprandial fullness | 54.1% | 72.9% | 59.5% | 0% | 84.2% | 62% | 0% |
Early satiation | 46.8% | 43.8% | 73.8% | 0% | 47.4% | 60.6% | 0% |
Epigastric pain or burning | 61.3% | 100% | 0% | 100% | 100% | 40.8% | 100% |
Postprandial epigastric pain or burning | 27% | 60.4% | 0% | 0% | 0% | 40.8% | 0% |
Chest pain | 60.4% | 64.6% | 40.5% | 66.7% | 74% | 47.9% | 66.7% |
Heartburn | 51.4% | 64.6% | 40.5% | 42.9% | 74% | 47.9% | 42.9% |
Characteristics and Symptoms | Rome III to Rome IV | p Value | |
---|---|---|---|
PDS to PDS | Overlap to PDS | ||
Patients (n) | 42 | 29 | |
Age (y) | 57.3 ± 12.4 | 49.3 ± 16.5 | 0.050 |
Gender (% female) | 69 | 82.8 | 0.198 |
BMI (kg/m²) | 21.4 ± 3.7 | 21.8 ± 3.2 | 0.717 |
Smoking | 16.7% | 20.7% | 0.675 |
Drinking | 19% | 27.6% | 0.405 |
After eradication of Helicobacter pylori | 14.3% | 24.1% | 0.299 |
Postprandial fullness | 59.5% | 65.5% | 0.617 |
Early satiation | 73.8% | 41.4% | 0.007 |
Epigastric pain or burning | 0% | 100% | |
Postprandial epigastric pain or burning | 0% | 100% | |
Chest pain | 40.5% | 62.1% | 0.236 |
Heartburn | 40.5% | 58.6% | 0.137 |
SF-8 | PDS to PDS | Overlap to PDS | p Value |
---|---|---|---|
Patients (n) | 42 | 29 | |
PF | 45.6 ± 9.4 | 42.8 ± 10.1 | 0.157 |
RP | 44.0 ± 9.5 | 42.6 ± 10.2 | 0.484 |
BP | 46.3 ± 8.8 | 41.5 ± 9.3 | 0.025 |
GH | 40.2 ± 7.1 | 39.1 ± 8.2 | 0.358 |
VT | 42.1 ± 9.0 | 43.1 ± 7.4 | 0.712 |
SF | 41.4 ± 11.2 | 39.2 ± 12.1 | 0.469 |
RE | 44.1 ± 9.2 | 42.3 ± 11.7 | 0.641 |
MH | 42.7 ± 7.2 | 42.8 ± 8.2 | 0.808 |
PCS | 43.9 ± 8.0 | 40.8 ± 9.7 | 0.124 |
MCS | 41.6 ± 9.0 | 42.0 ± 8.5 | 0.949 |
GSRS | PDS to PDS | Overlap to PDS | p Value |
---|---|---|---|
Patients (n) | 42 | 29 | |
Reflux | 2.8 ± 1.4 | 3.6 ± 1.6 | 0.025 |
Abdominal pain | 2.9 ± 1.2 | 3.7 ± 1.4 | 0.024 |
Dyspepsia | 2.9 ± 1.2 | 2.8 ± 1.3 | 0.449 |
Diarrhea | 2.2 ± 1.3 | 2.8 ± 1.8 | 0.138 |
Constipation | 3.1 ± 1.4 | 2.7 ± 1.2 | 0.245 |
Total score | 2.8 ± 0.90 | 3.1 ± 1.1 | 0.259 |
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Aono, S.; Tomita, T.; Tozawa, K.; Morishita, D.; Nakai, K.; Okugawa, T.; Fukushima, M.; Oshima, T.; Fukui, H.; Miwa, H. Epidemiology and Clinical Characteristics Based on the Rome III and IV Criteria of Japanese Patients with Functional Dyspepsia. J. Clin. Med. 2022, 11, 2342. https://doi.org/10.3390/jcm11092342
Aono S, Tomita T, Tozawa K, Morishita D, Nakai K, Okugawa T, Fukushima M, Oshima T, Fukui H, Miwa H. Epidemiology and Clinical Characteristics Based on the Rome III and IV Criteria of Japanese Patients with Functional Dyspepsia. Journal of Clinical Medicine. 2022; 11(9):2342. https://doi.org/10.3390/jcm11092342
Chicago/Turabian StyleAono, Sota, Toshihiko Tomita, Katsuyuki Tozawa, Daisuke Morishita, Keisuke Nakai, Takuya Okugawa, Masashi Fukushima, Tadayuki Oshima, Hirokazu Fukui, and Hiroto Miwa. 2022. "Epidemiology and Clinical Characteristics Based on the Rome III and IV Criteria of Japanese Patients with Functional Dyspepsia" Journal of Clinical Medicine 11, no. 9: 2342. https://doi.org/10.3390/jcm11092342