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Article

Seven COVID-19 Patients Treated with C-Reactive Protein (CRP) Apheresis

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Intensiv-Notfallmedizin und Kardiologie, Gemeinschaftskrankenhaus Havelhöhe, 14089 Berlin, Germany
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Gastroenterologie, Gemeinschaftskrankenhaus Havelhöhe, 14089 Berlin, Germany
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Medizinischen Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Charité-Universitätsmedizin, 12203 Berlin, Germany
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Institut für Sozialmedizin, Epidemiologie und Gesundheitsökonomie, Charité-Universitätsmedizin, 10117 Berlin, Germany
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Interdisziplinäre Onkologie und Supportivmedizin, Gemeinschaftskrankenhaus Havelhöhe, 14089 Berlin, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Ahmed Sheriff
J. Clin. Med. 2022, 11(7), 1956; https://doi.org/10.3390/jcm11071956
Received: 26 February 2022 / Revised: 24 March 2022 / Accepted: 26 March 2022 / Published: 1 April 2022
(This article belongs to the Special Issue C-Reactive Protein and Cardiovascular Disease: Clinical Aspects)
Background: The fulminant course of COVID-19, triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents with a high mortality rate and still lacks a causative treatment. C-reactive protein (CRP) has been shown to increase dramatically during the disease progression and correlates with deleterious outcomes. Selective CRP apheresis can reduce circulating CRP levels fast and effective. Methods: Seven hospitalized patients with documented severe COVID-19 progression, elevated CRP plasma levels (>100 mg/L) and signs of respiratory failure were treated with CRP apheresis. Two to twelve CRP apheresis sessions were performed generally in 24 h time intervals and depending on CRP plasma levels. Results: All patients had comorbidities. CRP apheresis reduced CRP plasma levels by up to 84% within a few hours, without exhibiting side effects in any patient. Despite signs of severe lung infiltration in all patients, only one patient died. The other patients showed improvements within the chest X-ray after CRP apheresis and were able to recover regardless of intubation and/or ECMO (4 patients). All remaining six patients were discharged from the hospital in good clinical condition. Conclusions: This case series presents a mortality rate of only 14%, which is dramatically lower than expected from the presented CRP levels as well as comorbidities and ventilation requirements. Our clinical observations regarding the here presented seven patients support the hypothesis that CRP is a candidate to be therapeutically targeted in the early stage of severe COVID-19. View Full-Text
Keywords: blood component removal; C-reactive protein; CRP apheresis; COVID-19; multiple organ failure; pulmonary fibrosis; SARS virus blood component removal; C-reactive protein; CRP apheresis; COVID-19; multiple organ failure; pulmonary fibrosis; SARS virus
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MDPI and ACS Style

Esposito, F.; Matthes, H.; Schad, F. Seven COVID-19 Patients Treated with C-Reactive Protein (CRP) Apheresis. J. Clin. Med. 2022, 11, 1956. https://doi.org/10.3390/jcm11071956

AMA Style

Esposito F, Matthes H, Schad F. Seven COVID-19 Patients Treated with C-Reactive Protein (CRP) Apheresis. Journal of Clinical Medicine. 2022; 11(7):1956. https://doi.org/10.3390/jcm11071956

Chicago/Turabian Style

Esposito, Fabrizio, Harald Matthes, and Friedemann Schad. 2022. "Seven COVID-19 Patients Treated with C-Reactive Protein (CRP) Apheresis" Journal of Clinical Medicine 11, no. 7: 1956. https://doi.org/10.3390/jcm11071956

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