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Article

Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study

1
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Bucheon 14647, Korea
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Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
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Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea
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Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea
5
Department of Statistics and Actuarial Science, Soongsil University, Seoul 06978, Korea
*
Authors to whom correspondence should be addressed.
Academic Editors: Gasparri Roberto, Manuel Scimeca, Alessandro Mauriello, Rita Bonfiglio and Nicola Fusco
J. Clin. Med. 2022, 11(4), 1077; https://doi.org/10.3390/jcm11041077
Received: 17 December 2021 / Revised: 15 February 2022 / Accepted: 16 February 2022 / Published: 18 February 2022
(This article belongs to the Topic Diagnostic Imaging and Pathology in Cancer Research)
Background: It is unclear whether the presence of minimal lung function impairment is an independent risk factor for the development of lung cancer in general populations. Methods: We conducted a population-based cohort study using nationally representative data from the Korean National Health and Nutrition Examination Survey and the Korean National Health Insurance Service. Results: Of 20,553 participants, 169 were diagnosed with lung cancer during follow-up (median, 6.5 years). Participants with obstructive lung function impairment had increased risk of lung cancer (aHR: 2.51; 95% CI: 1.729–3.629) compared with those with normal lung function. The lower was the quartile or decile of forced expiratory volume in one second (FEV1) or the FEV1/forced vital capacity (FVC) ratio, the significantly higher was the incidence rate of lung cancer (p for trend < 0.0001). With FEV1 values in the lowest quartile (Q4), the incidence of lung cancer was significantly increased regardless of FVC (FEV1 Q4 and FVC values in the higher three quartiles Q1–3: aHR 1.754; 95% CI 1.084–2.847, FEV1 Q4 and FVC Q4: aHR 1.889; 95% CI 1.331–2.681). Conclusion: Our findings suggest that minimal lung function impairment, as expressed by lower FEV1 or FEV1/FVC value, may be associated with increased risk of lung cancer View Full-Text
Keywords: lung cancer; pulmonary function test; lung function impairment lung cancer; pulmonary function test; lung function impairment
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MDPI and ACS Style

Kang, H.S.; Park, Y.-M.; Ko, S.-H.; Kim, S.H.; Kim, S.Y.; Kim, C.H.; Han, K.; Kim, S.K. Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study. J. Clin. Med. 2022, 11, 1077. https://doi.org/10.3390/jcm11041077

AMA Style

Kang HS, Park Y-M, Ko S-H, Kim SH, Kim SY, Kim CH, Han K, Kim SK. Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study. Journal of Clinical Medicine. 2022; 11(4):1077. https://doi.org/10.3390/jcm11041077

Chicago/Turabian Style

Kang, Hye Seon, Yong-Moon Park, Seung-Hyun Ko, Seung Hoon Kim, Shin Young Kim, Chi Hong Kim, Kyungdo Han, and Sung Kyoung Kim. 2022. "Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study" Journal of Clinical Medicine 11, no. 4: 1077. https://doi.org/10.3390/jcm11041077

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