Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Bucheon 14647, Korea

Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea

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Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea

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Department of Statistics and Actuarial Science, Soongsil University, Seoul 06978, Korea

Authors to whom correspondence should be addressed.

Academic Editors: Gasparri Roberto, Manuel Scimeca, Alessandro Mauriello, Rita Bonfiglio and Nicola Fusco

J. Clin. Med. 2022, 11(4), 1077; https://doi.org/10.3390/jcm11041077

Received: 17 December 2021 / Revised: 15 February 2022 / Accepted: 16 February 2022 / Published: 18 February 2022

(This article belongs to the Topic Diagnostic Imaging and Pathology in Cancer Research)

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Abstract

Background: It is unclear whether the presence of minimal lung function impairment is an independent risk factor for the development of lung cancer in general populations. Methods: We conducted a population-based cohort study using nationally representative data from the Korean National Health and Nutrition Examination Survey and the Korean National Health Insurance Service. Results: Of 20,553 participants, 169 were diagnosed with lung cancer during follow-up (median, 6.5 years). Participants with obstructive lung function impairment had increased risk of lung cancer (aHR: 2.51; 95% CI: 1.729–3.629) compared with those with normal lung function. The lower was the quartile or decile of forced expiratory volume in one second (FEV1) or the FEV1/forced vital capacity (FVC) ratio, the significantly higher was the incidence rate of lung cancer (p for trend < 0.0001). With FEV1 values in the lowest quartile (Q4), the incidence of lung cancer was significantly increased regardless of FVC (FEV1 Q4 and FVC values in the higher three quartiles Q1–3: aHR 1.754; 95% CI 1.084–2.847, FEV1 Q4 and FVC Q4: aHR 1.889; 95% CI 1.331–2.681). Conclusion: Our findings suggest that minimal lung function impairment, as expressed by lower FEV1 or FEV1/FVC value, may be associated with increased risk of lung cancer View Full-Text

Keywords: lung cancer; pulmonary function test; lung function impairment

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MDPI and ACS Style

Kang, H.S.; Park, Y.-M.; Ko, S.-H.; Kim, S.H.; Kim, S.Y.; Kim, C.H.; Han, K.; Kim, S.K. Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study. J. Clin. Med. 2022, 11, 1077. https://doi.org/10.3390/jcm11041077

AMA Style

Kang HS, Park Y-M, Ko S-H, Kim SH, Kim SY, Kim CH, Han K, Kim SK. Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study. Journal of Clinical Medicine. 2022; 11(4):1077. https://doi.org/10.3390/jcm11041077

Chicago/Turabian Style

Kang, Hye S., Yong-Moon Park, Seung-Hyun Ko, Seung H. Kim, Shin Y. Kim, Chi H. Kim, Kyungdo Han, and Sung K. Kim. 2022. "Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study" Journal of Clinical Medicine 11, no. 4: 1077. https://doi.org/10.3390/jcm11041077

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Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study

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