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Article

Diagnostic Interval in Extranodal Non-Hodgkin Head and Neck Lymphomas

by
Alba Bello Castro
1,*,
Juan Seoane
1,
Máximo Francisco Fraga Rodríguez
2,
Francisco Gude Sampedro
3,
Javier Seoane Romero
1,
Benjamín Martin-Biedma
1 and
Pablo Castelo-Baz
1
1
Department of Surgery and Medical-Surgical Specialties, School of Medicine and Dentistry, Universidade de Santiago de Compostela, Santiago de Compostela, 15705 La Coruña, Spain
2
Pathological Anatomy Unit, Universidade de Santiago de Compostela, 15705 La Coruña, Spain
3
Unit of Clinical Epidemiology, Clinical University Hospital of Santiago de Compostela, 15705 La Coruña, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(3), 853; https://doi.org/10.3390/jcm11030853
Submission received: 8 December 2021 / Revised: 25 January 2022 / Accepted: 3 February 2022 / Published: 6 February 2022
(This article belongs to the Section Otolaryngology)
Review Reports Versions Notes

Abstract

The aim of this study is to measure the diagnostic interval (DI) of primary extranodal non-Hodgkin lymphomas (PE-NHL) affecting the head and neck and to discover any associated factors. With this aim, we performed a retrospective observational study in northwestern Spain on patients diagnosed between 1 January 2005 and 1 January 2016. A search was made across the electronic health records of the public health system of this region (SERGAS). DI was used as the dependent variable, and different clinicopathological data of the corresponding patients and tumors were analyzed as exposure variables. PE-NHLs were mostly located in Waldeyer’s ring, and they presented a B phenotype and had a median DI of 65 days. Shorter diagnostic intervals were observed in (1) PE-NHL patients who had comorbidities (p = 0.02), (2) PE-NHL that caused symptoms of dysphagia (p = 0.04), (3) tumors with the highest proliferative activity (Ki67 > 80%) (p = 0.04), and (4) tumors diagnosed in the advanced stages of the disease (p = 0.004). Univariate analysis revealed a significant association between dysphagia and a shorter DI. We conclude that raising awareness about these neoplasms and warning about the presenting symptoms can contribute to earlier diagnoses of these tumors and to better outcomes.
Keywords: non-Hodgkin lymphomas; head and neck; diagnostic interval; diagnostic delay; dysphagia non-Hodgkin lymphomas; head and neck; diagnostic interval; diagnostic delay; dysphagia

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MDPI and ACS Style

Castro, A.B.; Seoane, J.; Rodríguez, M.F.F.; Sampedro, F.G.; Romero, J.S.; Martin-Biedma, B.; Castelo-Baz, P. Diagnostic Interval in Extranodal Non-Hodgkin Head and Neck Lymphomas. J. Clin. Med. 2022, 11, 853. https://doi.org/10.3390/jcm11030853

AMA Style

Castro AB, Seoane J, Rodríguez MFF, Sampedro FG, Romero JS, Martin-Biedma B, Castelo-Baz P. Diagnostic Interval in Extranodal Non-Hodgkin Head and Neck Lymphomas. Journal of Clinical Medicine. 2022; 11(3):853. https://doi.org/10.3390/jcm11030853

Chicago/Turabian Style

Castro, Alba Bello, Juan Seoane, Máximo Francisco Fraga Rodríguez, Francisco Gude Sampedro, Javier Seoane Romero, Benjamín Martin-Biedma, and Pablo Castelo-Baz. 2022. "Diagnostic Interval in Extranodal Non-Hodgkin Head and Neck Lymphomas" Journal of Clinical Medicine 11, no. 3: 853. https://doi.org/10.3390/jcm11030853

APA Style

Castro, A. B., Seoane, J., Rodríguez, M. F. F., Sampedro, F. G., Romero, J. S., Martin-Biedma, B., & Castelo-Baz, P. (2022). Diagnostic Interval in Extranodal Non-Hodgkin Head and Neck Lymphomas. Journal of Clinical Medicine, 11(3), 853. https://doi.org/10.3390/jcm11030853

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