Review Reports

Round 1

Reviewer 1 Report

In a paper by Gonzalez et al, the authors aimed to to evaluate the mid- and long-term FU of pts undergoing percutaneous closure of mitral PVL. During 10year study period, they were able to enroll 128 consecutive pts in whom 96 procedures were performed (73% were successful). It is as observational study yielding good long-term results of the PVL closure.

 My remarks:

1.       For PVL sizing, did the authors more rely on TEE or CT images or maybe intraprocedural angio or even balloon scoring? This aspect is also worth to be discussed later.

2.       What about ethical issues? Please add it in the methods section.

3.       Lines 129-134 should be place in the results section.

4.       Study limitation section should be added commenting on relatively low sample size and reasons for that.

5.       English language requires extensive editing. Please ask a native speaker for support.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The overall work is good. There are some corrections and additive materials to make it even better: 

1. Material and methods: please remove the sentence regarding animal 

2. Analyzed variables: please remove the word previously on line 80 

3. Missing reference in line 116

Please remove the paragraph starting on line 126 to the results section 

Results 

1. Please include numbers with only one decimal 

20% complication rate is not low. Please correct it throughout the entire manuscript 

Line 189: please correct the CI

Please replace the second paragraph of the results with the first one 

Please show all variables that were used in the univariate analysis 

What about ejection fraction, LA volume index, AF, etc., 

Table 1. Some words are not in English. Please mention below the units and acronyms used in the table

Include full names in the Kaplan-Meyer. 

Please add an LDH curve and MACE (continuous)

Remove X2 from brackets 

The discussion was too long. Focus on the adding value in your experience

Add central illustration 

Author Response

Please see the attachment.

Author Response File: Author Response.docx