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Article

MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate

by
Qi Zhang
1,†,
Jinran Lin
1,†,
Zhenghua Zhang
1,
Ling Han
1,
Qiong Huang
1,
Jie Zhu
1,
Bing Wang
1,
Xu Fang
1,
Zhizhong Zheng
1,
Nikhil Yawalkar
2,
Jun Liang
1,* and
Kexiang Yan
1,*
1
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China
2
Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2022, 11(15), 4580; https://doi.org/10.3390/jcm11154580
Submission received: 26 June 2022 / Revised: 3 August 2022 / Accepted: 3 August 2022 / Published: 5 August 2022
(This article belongs to the Section Dermatology)
Review Reports Versions Notes

Abstract

Background: Hyperhomocysteinemia has been reported in psoriasis. We investigated the effect of methylenetetrahydrofolate reductase (MTHFR), polymorphism and folic acid supplementation on serum homocysteine levels in psoriasis. Methods: Serum homocysteine levels were detected at baseline and at week 12 in 201 patients who were genotyped with MTHFR rs1801133 without and 93 psoriatic patients with folate supplement. Results: TT genotype carriers of MTHFR rs1801133 had significantly higher serum homocysteine levels at baseline and at week 12, a better PASI 75 response rate at week 8, and a higher PASI 90 response rate at week 12 than the CT and CC genotype carriers. Multiple regression analysis demonstrated that serum homocysteine concentration at baseline was significantly associated with sex, weight, PASI score at baseline, and the rs1801133 genotype. The significant upregulation of serum homocysteine levels after treatment with methotrexate (MTX) was only observed in male CT and CC genotype carriers and female CC genotype carriers. In contrast, folic acid supplementation significantly decreased serum homocysteine levels after MTX treatment but only in male psoriatic patients. Conclusions: The effect of MTX on serum homocysteine levels was associated with the polymorphism of MTHFR rs1801133 and sex. Folic acid supplementation only decreased serum homocysteine levels in male psoriatic patients.
Keywords: psoriasis; methylenetetrahydrofolate reductase; rs1801133; methotrexate; homocysteine psoriasis; methylenetetrahydrofolate reductase; rs1801133; methotrexate; homocysteine

Share and Cite

MDPI and ACS Style

Zhang, Q.; Lin, J.; Zhang, Z.; Han, L.; Huang, Q.; Zhu, J.; Wang, B.; Fang, X.; Zheng, Z.; Yawalkar, N.; et al. MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate. J. Clin. Med. 2022, 11, 4580. https://doi.org/10.3390/jcm11154580

AMA Style

Zhang Q, Lin J, Zhang Z, Han L, Huang Q, Zhu J, Wang B, Fang X, Zheng Z, Yawalkar N, et al. MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate. Journal of Clinical Medicine. 2022; 11(15):4580. https://doi.org/10.3390/jcm11154580

Chicago/Turabian Style

Zhang, Qi, Jinran Lin, Zhenghua Zhang, Ling Han, Qiong Huang, Jie Zhu, Bing Wang, Xu Fang, Zhizhong Zheng, Nikhil Yawalkar, and et al. 2022. "MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate" Journal of Clinical Medicine 11, no. 15: 4580. https://doi.org/10.3390/jcm11154580

APA Style

Zhang, Q., Lin, J., Zhang, Z., Han, L., Huang, Q., Zhu, J., Wang, B., Fang, X., Zheng, Z., Yawalkar, N., Liang, J., & Yan, K. (2022). MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate. Journal of Clinical Medicine, 11(15), 4580. https://doi.org/10.3390/jcm11154580

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