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Article

Prognostic Value of Catestatin in Severe COVID-19: An ICU-Based Study

1
Department of Anesthesiology and Intensive Care, University Hospital of Split, 21000 Split, Croatia
2
Department of Maxillofacial Surgery, University Hospital of Split, 21000 Split, Croatia
3
Department of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia
4
Department of Medical Laboratory Diagnostics, University Hospital of Split, 21000 Split, Croatia
5
Department of Health Studies, University of Split, 21000 Split, Croatia
6
Department of Anesthesiology and Intensive Care, University of Split School of Medicine, 21000 Split, Croatia
*
Author to whom correspondence should be addressed.
Academic Editors: Raffaele Marfella and Celestino Sardu
J. Clin. Med. 2022, 11(15), 4496; https://doi.org/10.3390/jcm11154496
Received: 8 July 2022 / Revised: 29 July 2022 / Accepted: 29 July 2022 / Published: 2 August 2022
Catestatin is a pleiotropic peptide with a wide range of immunomodulatory effects. Considering that patients with a severe COVID-19 infection have a major immunological dysregulation, the aim of this study was to evaluate catestatin levels in patients with COVID-19 treated in the intensive care unit (ICU) and to compare them between the fatal and non-fatal outcomes. The study included 152 patients with severe COVID-19, out of which 105 had a non-fatal outcome and 47 had a fatal outcome. Serum catestatin levels were estimated by an enzyme-linked immunosorbent assay in a commercially available diagnostic kit. The results show that catestatin levels were significantly lower in the fatal group compared to the non-fatal group (16.6 ± 7.8 vs. 23.2 ± 9.2 ng/mL; p < 0.001). Furthermore, there was a significant positive correlation between serum catestatin levels and vitamin D levels (r = 0.338; p < 0.001) while there was also a significant positive correlation between serum catestatin levels and growth differentiation factor-15 (GDF-15) levels (r = −0.345; p < 0.001). Furthermore, multivariate logistic regression showed that catestatin, GDF-15 and leukocyte count were significant predictors for COVID-19 survival. These findings imply that catestatin could be playing a major immunomodulatory role in the complex pathophysiology of the COVID-19 infection and that serum catestatin could also be a predictor of a poor COVID-19 outcome. View Full-Text
Keywords: SARS-CoV-2; COVID-19; catestatin; GDF-15; vitamin D; intensive care unit SARS-CoV-2; COVID-19; catestatin; GDF-15; vitamin D; intensive care unit
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MDPI and ACS Style

Kljakovic-Gaspic, T.; Tokic, D.; Martinovic, D.; Kumric, M.; Supe-Domic, D.; Stojanovic Stipic, S.; Delic, N.; Vrdoljak, J.; Vilovic, M.; Ticinovic Kurir, T.; Bozic, J. Prognostic Value of Catestatin in Severe COVID-19: An ICU-Based Study. J. Clin. Med. 2022, 11, 4496. https://doi.org/10.3390/jcm11154496

AMA Style

Kljakovic-Gaspic T, Tokic D, Martinovic D, Kumric M, Supe-Domic D, Stojanovic Stipic S, Delic N, Vrdoljak J, Vilovic M, Ticinovic Kurir T, Bozic J. Prognostic Value of Catestatin in Severe COVID-19: An ICU-Based Study. Journal of Clinical Medicine. 2022; 11(15):4496. https://doi.org/10.3390/jcm11154496

Chicago/Turabian Style

Kljakovic-Gaspic, Toni, Daria Tokic, Dinko Martinovic, Marko Kumric, Daniela Supe-Domic, Sanda Stojanovic Stipic, Nikola Delic, Josip Vrdoljak, Marino Vilovic, Tina Ticinovic Kurir, and Josko Bozic. 2022. "Prognostic Value of Catestatin in Severe COVID-19: An ICU-Based Study" Journal of Clinical Medicine 11, no. 15: 4496. https://doi.org/10.3390/jcm11154496

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