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Article

Safety and Feasibility of MitraClip Implantation in Patients with Acute Mitral Regurgitation after Recent Myocardial Infarction and Severe Left Ventricle Dysfunction

1
Heart Center, Kaplan Medical Center, Affiliated to the Hebrew University, Jerusalem 9190501, Israel
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Interventional Cardiology Unit, Hospital Álvaro Cunqueiro, 36321 Vigo, Spain
3
Interventional Cardiology Unit, Complejo Asistencial Universitario de Leon, 24071 Leon, Spain
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Cardiovascular Surgery Department, San Raffaele University Hospital, 20132 Milan, Italy
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Interventional Cardiology Unit, Hospital Sant Pau i Santa Creu, 08041 Barcelona, Spain
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Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia, 25123 Brescia, Italy
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Interventional Cardiology Unit, Hospital Clinic, 08036 Barcelona, Spain
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Hospital Clínico San Carlos, Instituto de Investigacion Sanitaria San Carlos, IdISSC, 28040 Madrid, Spain
9
Interventional Cardiology, The Center for Structural Heart Disease, Henry Ford Hospital, Detroit, MI 48202, USA
10
Department of Cardiology, Kantonsspital Baden, 5404 Baden, Switzerland
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Division of Cardiology, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
12
Department of Transcatheter Heart Valves, HYGEIA Hospital, 15123 Athens, Greece
13
Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada
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Department of Cardiology, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain
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Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
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Cardiovascular Institute, Baruch Padeh Medical Center, Poriya 1520800, Israel
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Department of Cardiology, Rambam Medical Center, and B. Rappaport Faculty of Medicine, Technion Medical School, Haifa 3109601, Israel
18
Department of Cardiology, Interbalkan European Medical Center, 55535 Thessaloniki, Greece
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Department of Cardiovascular Surgery, IRCCS Centro Cardiologico Monzino, 20138 Milan, Italy
20
Heart Valve Clinic, University Hospital of Zurich, 8006 Zurich, Switzerland
21
Heart Institute, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel
22
Cardiology Department, Rabin Medical Center and the “Sackler” Faculty of Medicine, Tel-Aviv University, Tel-Aviv 49100, Israel
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Department of Cardiology, Joan XXIII University Hospital, 43005 Tarragona, Spain
24
Jesselson Integrated Heart Centre, Shaare Zedek Medical Center, Hebrew University, Jerusalem 9103102, Israel
*
Author to whom correspondence should be addressed.
Equal Contribution.
Academic Editor: Bernward Lauer
J. Clin. Med. 2021, 10(9), 1819; https://doi.org/10.3390/jcm10091819
Received: 25 February 2021 / Revised: 5 April 2021 / Accepted: 13 April 2021 / Published: 22 April 2021
(This article belongs to the Special Issue Chronic Heart Failure and Depressed Systolic Function)
Patients with severe mitral regurgitation (MR) after myocardial infarction (MI) have an increased risk of mortality. Transcatheter mitral valve repair may therefore be a suitable therapy. However, data on clinical outcomes of patients in an acute setting are scarce, especially those with reduced left ventricle (LV) dysfunction. We conducted a multinational, collaborative data analysis from 21 centers for patients who were, within 90 days of acute MI, treated with MitraClip due to severe MR. The cohort was divided according to median left ventricle ejection fraction (LVEF)—35%. Included in the study were 105 patients. The mean age was 71 ± 10 years. Patients in the LVEF < 35% group were younger but with comparable Euroscore II, multivessel coronary artery disease, prior MI and coronary artery bypass graft surgery. Procedure time was comparable and acute success rate was high in both groups (94% vs. 90%, p = 0.728). MR grade was significantly reduced in both groups along with an immediate reduction in left atrial V-wave, pulmonary artery pressure and improvement in New York Heart Association (NYHA) class. In-hospital and 1-year mortality rates were not significantly different between the two groups (11% vs. 7%, p = 0.51 and 19% vs. 12%, p = 0.49) and neither was the 3-month re-hospitalization rate. In conclusion, MitraClip intervention in patients with acute severe functional mitral regurgitation (FMR) due to a recent MI in an acute setting is safe and feasible. Even patients with severe LV dysfunction may benefit from transcatheter mitral valve intervention and should not be excluded. View Full-Text
Keywords: mitral regurgitation; percutaneous mitral valve repair; acute myocardial infarction; left ventricle dysfunction mitral regurgitation; percutaneous mitral valve repair; acute myocardial infarction; left ventricle dysfunction
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MDPI and ACS Style

Haberman, D.; Estévez-Loureiro, R.; Benito-Gonzalez, T.; Denti, P.; Arzamendi, D.; Adamo, M.; Freixa, X.; Nombela-Franco, L.; Villablanca, P.; Krivoshei, L.; Fam, N.; Spargias, K.; Czarnecki, A.; Pascual, I.; Praz, F.; Sudarsky, D.; Kerner, A.; Ninios, V.; Gennari, M.; Beeri, R.; Perl, L.; Danenberg, H.; Poles, L.; Shimoni, S.; Goland, S.; Caneiro-Queija, B.; Scianna, S.; Moaraf, I.; Schiavi, D.; Scardino, C.; Corpataux, N.; Echarte-Morales, J.; Chrissoheris, M.; Fernández-Peregrina, E.; Di Pasquale, M.; Regueiro, A.; Vergara-Uzcategui, C.; Iñiguez-Romo, A.; Fernández-Vázquez, F.; Dvir, D.; Taramasso, M.; Shuvy, M. Safety and Feasibility of MitraClip Implantation in Patients with Acute Mitral Regurgitation after Recent Myocardial Infarction and Severe Left Ventricle Dysfunction. J. Clin. Med. 2021, 10, 1819. https://doi.org/10.3390/jcm10091819

AMA Style

Haberman D, Estévez-Loureiro R, Benito-Gonzalez T, Denti P, Arzamendi D, Adamo M, Freixa X, Nombela-Franco L, Villablanca P, Krivoshei L, Fam N, Spargias K, Czarnecki A, Pascual I, Praz F, Sudarsky D, Kerner A, Ninios V, Gennari M, Beeri R, Perl L, Danenberg H, Poles L, Shimoni S, Goland S, Caneiro-Queija B, Scianna S, Moaraf I, Schiavi D, Scardino C, Corpataux N, Echarte-Morales J, Chrissoheris M, Fernández-Peregrina E, Di Pasquale M, Regueiro A, Vergara-Uzcategui C, Iñiguez-Romo A, Fernández-Vázquez F, Dvir D, Taramasso M, Shuvy M. Safety and Feasibility of MitraClip Implantation in Patients with Acute Mitral Regurgitation after Recent Myocardial Infarction and Severe Left Ventricle Dysfunction. Journal of Clinical Medicine. 2021; 10(9):1819. https://doi.org/10.3390/jcm10091819

Chicago/Turabian Style

Haberman, Dan, Rodrigo Estévez-Loureiro, Tomas Benito-Gonzalez, Paolo Denti, Dabit Arzamendi, Marianna Adamo, Xavier Freixa, Luis Nombela-Franco, Pedro Villablanca, Lian Krivoshei, Neil Fam, Konstantinos Spargias, Andrew Czarnecki, Isaac Pascual, Fabien Praz, Doron Sudarsky, Arthur Kerner, Vlasis Ninios, Marco Gennari, Ronen Beeri, Leor Perl, Haim Danenberg, Lion Poles, Sara Shimoni, Sorel Goland, Berenice Caneiro-Queija, Salvatore Scianna, Igal Moaraf, Davide Schiavi, Claudia Scardino, Noé Corpataux, Julio Echarte-Morales, Michael Chrissoheris, Estefanía Fernández-Peregrina, Mattia Di Pasquale, Ander Regueiro, Carlos Vergara-Uzcategui, Andres Iñiguez-Romo, Felipe Fernández-Vázquez, Danny Dvir, Maurizio Taramasso, and Mony Shuvy. 2021. "Safety and Feasibility of MitraClip Implantation in Patients with Acute Mitral Regurgitation after Recent Myocardial Infarction and Severe Left Ventricle Dysfunction" Journal of Clinical Medicine 10, no. 9: 1819. https://doi.org/10.3390/jcm10091819

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