Statin Use Is Associated with a Decreased Risk of Mortality among Patients with COVID-19
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Department of Healthcare Information and Management, School of Health Technology, Ming Chuan University, Taipei 333, Taiwan
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Department of Exercise and Health Promotion, College of Kinesiology and Health, Chinese Culture University, 55 Yangmingshan, Huagang Road, Shilin District, Taipei 11114, Taiwan
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Southeast Asian, Cross-Strait and Overseas Student Institute, Ming Chuan University, Taipei 333, Taiwan
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Graduate Institute of Sport Coaching Science, College of Kinesiology and Health, Chinese Culture University, Taipei 11114, Taiwan
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Taiwan College of Healthcare Executives, 9F No. 95, Sec. 3, Roosevelt Rd., Da’an District, Taipei City 106607, Taiwan
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Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
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Author to whom correspondence should be addressed.
Academic Editor: Vito Racanelli
J. Clin. Med. 2021, 10(7), 1450; https://doi.org/10.3390/jcm10071450
Received: 3 March 2021
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Revised: 25 March 2021
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Accepted: 26 March 2021
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Published: 1 April 2021
(This article belongs to the Collection Coronavirus Disease 2019: Clinical Presentation, Pathogenesis and Treatment)
Background: Recent epidemiological studies remain controversial regarding the association between statin use and reducing the risk of mortality among individuals with COVID-19. Objective: The objective of this study was to clarify the association between statin use and the risk of mortality among patients with COVID-19. Methods: We conducted a systematic articles search of online databases (PubMed, EMBASE, Scopus, and Web of Science) between 1 February 2020 and 20 February 2021, with no restriction on language. The following search terms were used: “Statins” and “COVID-19 mortality or COVID19 mortality or SARS-CoV-2 related mortality”. Two authors individually examined all articles and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for study inclusion and exclusion. The overall risk ratio (RRs) with 95% confidence interval (CI) was calculated to show the strength of the association and the heterogeneity among the studies was presented Q and I2 statistic. Results: Twenty-eight studies were assessed for eligibility and 22 studies met the inclusion criteria. Statin use was associated with a significantly decreased risk of mortality among patients with COVID-19 (RR adjusted = 0.64; 95% CI: 0.57–0.72, p < 0.001). Moreover, statin use both before and after the admission was associated with lowering the risk of mortality among the COVID-19 patients (RR adjusted;before = 0.69; 95% CI: 0.56–0.84, p < 0.001 and RR adjusted;after = 0.57; 95% CI: 0.54–0.60, p < 0.001). Conclusion: This comprehensive study showed that statin use is associated with a decreased risk of mortality among individuals with COVID-19. A randomized control trial is needed to confirm and refute the association between them.
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Keywords:
statin; COVID-19; SARS-CoV-2; mortality risk; diabetes
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MDPI and ACS Style
Wu, C.-C.; Lee, A.-J.; Su, C.-H.; Huang, C.-Y.; Islam, M.M.; Weng, Y.-C. Statin Use Is Associated with a Decreased Risk of Mortality among Patients with COVID-19. J. Clin. Med. 2021, 10, 1450. https://doi.org/10.3390/jcm10071450
AMA Style
Wu C-C, Lee A-J, Su C-H, Huang C-Y, Islam MM, Weng Y-C. Statin Use Is Associated with a Decreased Risk of Mortality among Patients with COVID-19. Journal of Clinical Medicine. 2021; 10(7):1450. https://doi.org/10.3390/jcm10071450
Chicago/Turabian StyleWu, Chieh-Chen, An-Jen Lee, Chun-Hsien Su, Chu-Ya Huang, Md. M. Islam, and Yung-Ching Weng. 2021. "Statin Use Is Associated with a Decreased Risk of Mortality among Patients with COVID-19" Journal of Clinical Medicine 10, no. 7: 1450. https://doi.org/10.3390/jcm10071450
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